SET Protein as an Epigenetics Target

Abstract

The SET gene has four transcripts reported in NCBI, coding two isoforms of SET proteins. The most known function of SET protein is inhibiting protein phosphatase 2A, a tumor suppressor, which has been associated with different biological processes. In this review, our focus was on exploring the other SET functions related to epigenetic mechanisms, which impact cellular migration, cell cycle and apoptosis.

Tweetable abstract

SET protein is responsible for regulating essential epigenetic processes. The disrupted function of SET in cancer makes it a promising target for research.

Keywords::

• Alzheimer’s
• cancer
• epigenetics
• I2PP2A
• SET protein

Acknowledgments

The authors would like to thank the web-based tool Biorender for the development of the images presented in this article.

Financial disclosure

Authors are grateful for financial support provided by Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP research grant no. 2016/19103-2, 2023/01454-7; scholarship no. 2020/00101-5; 2023/09624-9; 2021/03732-9; 2022/10740-0), CNPq and CAPES (CAPES-001), Brazil. The authors have no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript apart from those disclosed.

Competing interests disclosure

The authors have no competing interests or relevant affiliations with any organization or entity with the subject matter or materials discussed in the manuscript. This includes employment, consultancies, honoraria, stock ownership or options, expert testimony, grants or patents received or pending, or royalties.

Writing disclosure

No writing assistance was utilized in the production of this manuscript.

Additional information

Funding

Authors are grateful for financial support provided by Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP research grant no. 2016/19103-2, 2023/01454-7; scholarship no. 2020/00101-5; 2023/09624-9; 2021/03732-9; 2022/10740-0), CNPq and CAPES (CAPES-001), Brazil. The authors have no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript apart from those disclosed.