Abstract
Helicobacter pylori, a Gram-negative microaerobic bacteria belonging to the phylum Proteobacteria, can colonize in the stomach and duodenum, and cause a series of gastrointestinal diseases such as gastritis, gastric ulcer and even gastric cancer. At present, the high diversity of the microorganisms in the stomach has been confirmed with culture-independent methods; some researchers have also studied the stomach microbiota composition at different stages of H. pylori carcinogenesis. Here, we mainly review the possible role of H. pylori-mediated microbiota changes in the occurrence and development of gastric cancer to provide new ideas for preventing H. pylori infection and regulating microecological imbalance.
Author contributions
H Cong and A Chen established the original concept and design. Z Wang, S Shao, X Xu, M Wang and X Zhao conducted literature retrieval and data analysis. Z Wang, S Shao, A Chen and H Cong wrote the manuscript and designed the figures. All authors approved the final version of the article, including the authorship list.
Financial & competing interests disclosure
This study was funded in part by Shandong Provincial Natural Science Foundation, China (grant no. ZR2020MH296 and ZR2021QH236). The authors have no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript apart from those disclosed.
No writing assistance was utilized in the production of this manuscript.