In Vitro Activity of the Novel Fe-Cyclam Complex Against Clinical Multidrug-Resistant Bacterial Isolates From Brazil

Abstract

Aim: To evaluate the effect of a new Fe-cyclam complex on pathogenic bacterial species, including multidrug-resistant clinical specimens. Materials & methods: The complex [Fe(cyclam)ox]PF₆ (D2) was tested in cytotoxicity and MIC tests. Clinical and reference strains of Gram-negative and Gram-positive bacteria were used. Considering Staphylococcus aureus strains, the profile of antimicrobial susceptibility and time–kill kinetics for D2 was performed. An in silico analysis for D2 was also performed. Results: D2 showed broad bacterial activity, mainly against specimens of Cutibacterium acnes, S. aureus, Pseudomonas aeruginosa and Acinetobacter baumannii. Low cytotoxicity in human cells was demonstrated. Conclusion: The tested compound proved to be a promising agent against resistant bacterial infections.

Graphical abstract

Keywords::

• Acinetobacter baumannii
• antibacterial agents
• bacterial
• drug resistance
• Pseudomonas aeruginosa
• Staphylococcus aureus

Acknowledgments

The authors would like to thank R Villela Bastos, V Quinet de Andrade Bastos, L Quinet de Andrade Bastos and V Cordeiro Dias for their partnership in the supply of isolates, and V Batista Clemente for English revision.

Financial & competing interests disclosure

This study was financed in part by the Coordenalção de Aperfeiçoamento de Pessoal de Nível Superior – Brasil (CAPES) – Finance Code 001 and the Federal University of Juiz de Fora. The authors have no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript apart from those disclosed.

No writing assistance was utilized in the production of this manuscript.

Additional information

Funding

This study was financed in part by the Coordenalção de Aperfeiçoamento de Pessoal de Nível Superior – Brasil (CAPES) – Finance Code 001 and the Federal University of Juiz de Fora. The authors have no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript apart from those disclosed.