Abstract
Aim: This study analyzed clinicopathological features of colorectal mucinous carcinoma and their prognostic values. Patients&method: This study enrolled 265 patients with mucinous colorectal cancer. Clinicopathological information and prognosis were reviewed retrospectively. Kaplan–Meier method, log- rank test and COX proportional hazard regression models were used. Results: In postoperative mucinous carcinoma patients (median age 56, 119 [44.9%] female), advanced tumor stage (odds ratio [OR]: 2.378; 95% CI: 1.512–3.741; p = 0.0002), poor differentiation (OR: 1.896; CI: 1.217–2.955; p = 0.0047) and right-sided tumors (OR: 2.421; CI: 1.145–5.102; p = 0.0206) were associated with shorter overall survival. Appendiceal/ileocecal cecal tumors were not different for prognosis. Conclusion: Mucinous colorectal carcinoma exhibits distinct tumor characteristics. Poor differentiation, advanced stage at presentation and the right side serve as negative prognostic factors.
Financial&competing interests disclosure
The funding source was from Natural Science Foundation of Zhejiang Province (grant no. LY15H160003), which supported research infrastructure. The authors have no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript. This includes employment, consultancies, honoraria, stock ownership or options, expert testimony, grants or patents received or pending, or royalties.
No writing assistance was utilized in the production of this manuscript.
Ethical conduct of research
The authors state that the research has been reviewed by the Medical Ethics Committee of Zhejiang Cancer Hospital and was approved by the board of ethics committee. In addition, for investigations involving human subjects, informed consent has been obtained from the participants involved.