Abstract
Aims: To investigate the prognostic value of hemoglobin combined with geriatric nutritional risk index (GNRI) scores in patients undergoing postoperative radiotherapy for esophageal squamous cell carcinoma (ESCC). Patients & methods: Patients who underwent esophagectomy and postoperative radiotherapy were included in this retrospective study. Their preoperative hemoglobin and GNRI were collected to establish hemoglobin-GNRI (H-GNRI) scores, and their association with OS was evaluated. Results: Patients with high H-GNRI scores had better prognosis than those with low scores (p < 0.001). Differentiation (p = 0.001), T classification (p = 0.010), N classification (p = 0.001) and H-GNRI score (p = 0.018) were independent prognostic factors for all patients. Conclusion: H-GNRI score is an independent prognostic factor for the survival of patients with ESCC managed by surgery and postoperative radiotherapy.
Supplementary data
To view the supplementary data that accompany this paper please visit the journal website at: www.tandfonline.com/doi/suppl/10.2217/fon-2021-0439
Author contributions
W Geng directed this study. B Wang, K Ying and J Chu were responsible for case collection, data analysis and manuscript writing. C Xu conducted the literature review at the early stage of the study design. All the authors made substantial contributions to this study and approved the submitted manuscript.
Financial & competing interests disclosure
This study was supported by the Medical Science and Technology Development Project of Yancheng (YK2019007, YK2020025). The authors have no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript apart from those disclosed.
No writing assistance was utilized in the production of this manuscript.
Ethical conduct of research
The authors state that they have obtained appropriate institutional review board from Ethics Committee of the Affiliated Yancheng First Hospital of Nanjing University Medical School approval or have followed the principles outlined in the Declaration of Helsinki for all human or animal experimental investigations.