Host Proteins Involved in microtubule-dependent HIV-1 Intracellular Transport and Uncoating

Abstract

Microtubules and microtubule-associated proteins are critical for cargo transport throughout the cell. Many viruses are able to usurp these transport systems for their own replication and spread. HIV-1 utilizes these proteins for many of its early events postentry, including transport, uncoating and reverse transcription. The molecular motor proteins dynein and kinesin-1 are the primary drivers of cargo transport, and HIV-1 utilizes these proteins for infection. In this Review, we highlight recent developments in the understanding of how HIV-1 hijacks motor transport, the key cellular and viral proteins involved, and the ways that transport influences other steps in the HIV-1 lifecycle.

Keywords:

• dynein
• HIV-1
• infection
• kinesin
• microtubule
• motor proteins
• reverse transcription
• transport
• uncoating

Financial & competing interests disclosures

SK Carnes received funding from NIH (grant number: F31 AI129747-01A1). The authors have no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript apart from those disclosed.

No writing assistance was utilized in the production of this manuscript.