Genetic polymorphisms of OPRM1 on the Efficacy and Safety of Anesthetic and Analgesic Agents: A Systematic Review

Abstract

Aim: This systematic review aimed to outline the outcome of OPRMI (A118G) variants on the effects of anesthetic and analgesic agents used in various procedures. Materials & methods: Literature was obtained from reliable, established databases and reference tracking. Efficacy and side/adverse effects of anesthetic and analgesic drugs intraoperatively or within 48 h postsurgery were the key outcome measures for all populations. Animal studies were excluded. Results: Twenty-nine studies were chosen for inclusion. In association with the efficacy and safety of anesthetic and analgesic agents, gene polymorphism in OPRM1 displayed a strong correlation in reduced analgesic effect and protection against adverse reactions. Conclusion: This systematic review summarized the correlation between genetic polymorphism in the OPRM1 gene and anesthetic/analgesic effects.

Keywords::

• A118G
• anesthesia
• analgesia
• genetic polymorphism
• OPRM1

Author contributions

M Makmor-Bakry was responsible for the study conception and design; L Yee and M Makmor-Bakry were responsible for the acquisition of data; L Yee, M Makmor-Bakry and FR Capule were responsible for data analysis and drafting and revision of the manuscript.

Financial & competing interests disclosure

This study was supported by the Fundamental Research Grant Scheme, Malaysian Ministry of Higher Education (FRGS/1/2019/SKK09/UKM/02/4). The authors have no other relevant afflictions or financial involvement with any organization or entity with a financial interest or financial conflict with the subject matter or materials discussed in the manuscript apart from those disclosed.

No writing assistance was utilized in the production of this manuscript.

Additional information

Funding

This study was supported by the Fundamental Research Grant Scheme, Malaysian Ministry of Higher Education (FRGS/1/2019/SKK09/UKM/02/4). The authors have no other relevant afflictions or financial involvement with any organization or entity with a financial interest or financial conflict with the subject matter or materials discussed in the manuscript apart from those disclosed. No writing assistance was utilized in the production of this manuscript.