Association of OPRK1 rs963549 and rs997917 Polymorphisms With Opioid Use Disorder and Related Phenotypes

Abstract

Aim: To evaluate the association between OPRK1 rs963549 and rs997917 and opioid use disorder (OUD) and related phenotypes. Methods: A sample of 208 individuals with (n = 100) and without (n = 108) OUD were enrolled. OPRK1 rs963549 and rs997917 were analyzed by PCR–RFLP. Craving, opioid withdrawal and the intensity of depressive and anxiety symptoms were measured by the appropriate scales. Results:OPRK1 rs963549 variation showed a trend of association with decreased opioid withdrawal. No significant associations were found between OPRK1 rs963549 and rs997917 polymorphisms and craving, depression or anxiety symptoms. Neither single OPRK1 SNPs nor OPRK1 haplotypes were associated with OUD. Conclusion: Our results could be useful for treatment failures of individuals who experience greater opioid withdrawal due to their OPRK1 rs963549 genotypes.

Keywords::

• individual differences
• κ-opioid receptor
• opioid use disorder
• opioid withdrawal
• OPRK1 gene

Financial & competing interests disclosure

This study was supported by the Ankara University Scientific Research Projects Coordination Unit (grant no. 20H0217001 awarded to D Kaya-Akyüzlü). The authors have no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript apart from those disclosed.

No writing assistance was utilized in the production of this manuscript.

Additional information

Funding

This study was supported by the Ankara University Scientific Research Projects Coordination Unit (grant no. 20H0217001 awarded to D Kaya-Akyüzlü). The authors have no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript apart from those disclosed. No writing assistance was utilized in the production of this manuscript.