Formulation and Characterization of Glibenclamide and quercetin-loaded Chitosan Nanogels Targeting Skin Permeation

Abstract

Aim: Our aim was to develop and characterize a nanogel formulation containing both glibenclamide and quercetin and to explore the permeation profile of this combination. Methods: Drug-loaded nanogel was prepared by ionic gelation. In addition, optimum encapsulation efficiencies of glibenclamide and quercetin were also obtained. The average nanoparticle size at optimum conditions was determined by Zetasizer. Results: The particle size of the nanogel was found to be 370.4 ± 4.78 nm with a polydispersity index of 0.528 ± 0.04, while the λ potential was positive in a range of 17.6 to 24.8 mV. The percentage cumulative drug release also showed favorable findings. Conclusion: The chitosan nanogel could be a potential alternative for delivering glibenclamide and quercetin through skin.

Keywords:

• chitosan
• glibenclamide
• quercetin
• skin-permeating nanogel

Financial & competing interests disclosure

This research was supported by a grant from the International Medical University (IMU), Malaysia (Project ID No-BP I-01-14 (31)2017). The authors have no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript apart from those disclosed.

No writing assistance was utilized in the production of this manuscript.

Author contributions

DK Chellappan, NJ Yee and BJ Kaur: Laboratory work and writing article; G Gupta, K Dua and M Gulati: Study Design; J Panneerselvam, J Chellian and T Madheswaran: Statistical analysis; S Satija and M Mehta: Proof reading. All authors had full access to all data in the study and take responsibility for the integrity of the data and the accuracy of the data analysis.