Plasma levels of soluble endothelial protein C-receptor in patients with β-thalassemia

Available online 25 September 2012

Peer review under responsibility of Alexandria University Faculty of Medicine.

Figures & data

Table 1 Hematological parameters in patients compared to control.

		Cases	Control	Z	P^#
Hb (g/dl)	Mean ± SD	7.6 ± 1.1	13.2 ± 0.8	−6.657	0.000^*
	Min–Max	5.7–10.8	11.9–14.6
	Median	7.5	13.0
RBC (×10^12 L^−1)	Mean ± SD	2.9 ± 0.6	4.2 ± 0.6	−4.411	0.000^*
	Min–Max	1.9–4.6	4.0–5.1
	Median	2.9	4.8
MCV (Fl)	Mean ± SD	67.9 ± 6.9	84.6 ± 3.0	−6.567	0.000^*
	Min–Max	50.3–79.2	78.2–88.9
	Median	69.9	85.2
WBC (×10^9 L^−1)	Mean ± SD	9.8 ± 2.9	6.9 ± 1.5	−4.217	0.000^*
	Min–Max	5.3–19.2	4.3–9.1
	Median	9.4	6.9
Platelets (×10^9 L^−1)	Mean ± SD	428.1 ± 193.9	318.8 ± 70.6	−2.329	0.020^*
	Min–Max	141.0–793.0	198.0–423.0
	Median	450.0	321.0
MPV (Fl)	Mean ± SD	9.2 ± 1.2	9.1 ± 0.8	−0.415	0.679
	Min–Max	7.1–11.4	7.8–10.4
	Median	9.4	9.1
Normoblasts/100WBCs	Mean ± SD	21.9 ± 38.6	0.0 ± 0.0	−7.114	0.000^*
	Min–Max	4.0–222.0	0.0 ± 0.0
	Median	12.5	0.0
Absolute reticulocytic count	Mean ± SD	130,500 ± 11.2	42,000 ± 01.3	−6.663	0.000^*
	Min–Max	47,500–345,000	24,000–81,600
	Median	130,500	48,000

# P value based on Mann–Whitney test.

* P < 0.05 (significant).

Table 2 Hematological parameters in group I compared to group II.

		Group I	Group II	Z	P^#
Hb (g/dl)	Mean ± SD	7.8 ± 0.8	7.5 ± 1.3	−1.268	0.217
	Min–Max	6.3–9.5	5.7–10.8
	Median	7.5	7.1
RBC (×10^12 L^−1)	Mean ± SD	3.1 ± 0.6	2.8 ± 0.7	−6.628	0.351
	Min–Max	2.3–4.6	1.9–3.9
	Median	3.2	2.6
MCV (Fl)	Mean ± SD	67.1 ± 7.1	68.9 ± 6.9	−0.954	0.340
	Min–Max	50.3–78.3	55.5–79.2
	Median	68.9	70.8
WBC (×10^9 L^−1)	Mean ± SD	9.8 ± 2.1	9.9 ± 3.7	−0.394	0.693
	Min–Max	6.4–13.4	5.3–19.2
	Median	9.6	9.2
Platelets (×10^9 L^−1)	Mean ± SD	561.5 ± 150.7	294.6 ± 130.4	−3.859	0.000^*
	Min–Max	252.0–793.0	141.0–607.0
	Median	532.0	298.0
MPV (Fl)	Mean ± SD	9.6 ± 1.1	8.9 ± 1.2	−1.619	0.106
	Min–Max	7.5–11.1	7.1–11.4
	Median	9.6	8.7
Normoblasts/100WBCs	Mean ± SD	34.0 ± 52.5	9.8 ± 3.5	−3.636	0.000^*
	Min–Max	5.0–222.0	4.0–16.0
	Median	24.0	10.0
Absolute reticulocytic count	Mean ± SD	142,600 ± 11.4	120,400 ± 01.9	−0.851	0.412
	Min–Max	62,100–345,000	47,500–237,900
	Median	156,800	106,600

# P-value based on Mann–Whitney test.

* P < 0.05 (significant).

Table 3 Coagulation parameters in patients compared to control.

		Cases	Control	Z	P
INR	Mean ± SD	1.2 ± 0.2	1.04 ± 0.01	−6.927	0.000^*
	Min–Max	1.0–1.8	1.0–1.1
	Median	1.3	1.09
PTT (seconds)	Mean ± SD	41.2 ± 6.6	35.1 ± 2.0	−3.942	0.000^*
	Min–Max	32.1–61.2	32.1–38.2
	Median	40.2	35.2

* P < 0.05 (significant).

Table 4 Coagulation parameters in group 1 compared to group 2.

	Group 1	Group 2	Z	P
INR
Mean ± SD	1.3 ± 0.2	1.2 ± 0.2	−0.664	0.507
Min–Max	1.1–1.8	1.0–1.5
Median	1.3	1.3
PTT (seconds)
Mean ± SD	42.1 ± 7.2	40.3 ± 6.1	−0.602	0.547
Min–Max	32.1–61.2	33.0–52.0
Median	41.9	38.0

Table 5 sEPCR level in patients compared to control.

sEPCR (ng/ml)	Cases	Control	Z	P
Mean ± SD	265.6 ± 255.1	106.3 ± 46.1	−2.632	0.008^*
Min–Max	38.7–1073.1	20.0–151.3
Median	157.4	129.6

* P < 0.05 (significant).

Table 6 sEPCR level in group 1 compared to group 2.

sEPCR (ng/ml)	Group 1	Group 2	Z	P
Mean ± SD	309.9 ± 314.4	221.1 ± 177.9	−0.373	0.709
Min–Max	38.7–1073.1	40.0–600.0
Median	160.0	144.7

Table 7 sEPCR level in group 1 compared to control.

sEPCR (ng/ml)	Cases	Control	Z	P
Mean ± SD	309.9 ± 314.5	106.3 ± 46.1	−2.312	0.021^*
Min–Max	38.7–1073.1	20.0–151.3
Median	160.0	129.6

* P < 0.05 (significant).

Table 8 sEPCR level in group 2 compared to control.

sEPCR (ng/ml)	Group 2	Control	Z	P
Mean ± SD	221.1 ± 177.9	106.3 ± 46.1	−1.975	0.048^*
Min–Max	40.0–600.0	20.0–151.3
Median	144.7	129.6

* P < 0.05 (significant).

Figure 1 Correlation between sEPCR and WBC count.

Figure 2 Correlation between sEPCR and platelet counts.