Relation between Helicobacter pylori and atrophic gastritis in elderly: Estimation of serum (gastrin 17 and pepsinogen-I) as novel biomarkers

Available online 1 September 2012

Peer review under responsibility of Alexandria University Faculty of Medicine.

Figures & data

Table 1 Demographic data in the studied groups.

	H. pylori	n	Min	Max	Mean	SD	t	P
Age (years)	Negative	30	62	81	69.4	5.04	0.585	0.561
	Positive	30	65	78	70.1	3.69
BMI (kg/m^2)	Negative	30	17	24	21.2	2.20	0.483	0.631
	Positive	30	17	24	20.9	2.07

^∗P is significant if <0.05.

Table 2 Relation between degree of gastritis and the other parameters.

	Gastritis degree	n	Mean	SD	F	P	LSD
Pepsinogen 1	Superficial	27	122.4	41.75	56.052	0.000^*	Superficial vs others Mild vs moderate and severe
	Mild	9	66.0	22.36
	Moderate	11	19.6	4.34
	Severe	13	9.6	5.31
Pepsinogen 2	Superficial	27	52.3	27.31	10.399	0.000^*	Superficial and mild vs moderate and severe
	Mild	9	40.8	28.90
	Moderate	11	18.5	17.03
	Severe	13	13.3	14.23
Pepsinogen 1/2 ratio	Superficial	27	3.7	3.85	3.606	0.041^*	Superficial and mild vs moderate and severe
	Mild	9	3.2	3.23
	Moderate	11	1.8	1.01
	Severe	13	1.2	1.06
Gastrin	Superficial	27	31.4	25.29	3.169	0.031^*	Superficial and mild vs moderate and severe
	Mild	9	31.3	20.07
	Moderate	11	15.8	11.19
	Severe	13	15.3	5.22
H. pylori antibody	Superficial	27	16.6	4.09	37.575	0.000^*	Superficial vs others
	Mild	9	34.5	13.85
	Moderate	11	37.4	4.84
	Severe	13	41.4	10.60

* P is significant if <0.05.

Figure 1 Relation between degree of gastritis and pepsinogen I and II.

Table 3 Relation between H. pylori and degree of gastritis.

	H. pylori		X2	P
	Negative	Positive
Superficial	27
	90.0%
Mild	3	6
	10.0%	20.0%
Moderate		11	57.00	0.000^*
		36.7%
Severe		13
		43.3%
	30	30

* P is significant if <0.05.

Figure 2 Relation between degree of gastritis and pepsinogen I/II ratio.

Figure 3 Relation between degree of gastritis and serum gastrin.

Figure 4 Relation between degree of gastritis and H. pylori antibody.

Table 4 Evaluation of different markers in prediction of atrophic gastritis.

	Cut off value	Sensitivity	Specificity	Positive predictive value	Negative predictive value	Accuracy
Serum pepsinogen 1	<97	100.0	81.5	86.8	100.0	91.7
Serum pepsinogen 2	<52	93.9	63.0	75.6	89.5	80.0
Serum pepsinogen 1/2 ratio	<1.82	66.7	66.7	71.0	62.1	66.7
Serum gastrin	<28	90.9	44.4	66.7	80.0	70.0