The role of diffusion weighted magnetic resonance imaging in assessment of normal myelination in infantile brain

Peer review under responsibility of Alexandria University Faculty of Medicine.

Available online 16 June 2015

Figures & data

Table

Supra tentorial region (7 sites)	• Genu and splenium of the corpus callosum. • Anterior and posterior limb of the internal capsule. • Corona radiata. • Centrum semiovale (pre and post central gyrus).
Infra tentorial region (3 sites)	• Middle cerebellar peduncle. • Ventral aspects of the brain stem at the level of the pons. • Dorsal aspects of the brain stem at the level of the pons.

Table 1 Distribution of the studied cases according to demographic data (n = 30).

	No.	%
Sex
Male	13	43.3
Female	17	56.7
Age (month)
Min.–Max.	1.0–36.0
Mean ± SD	15.10 ± 9.63
Median	13.0

Table 2 Distribution of the measured ADC values in the selected white matter areas.

	Min.–Max.	Mean ± SD	Median
Middle cerebellar peduncle	0.62–1.32	0.81 ± 0.16	0.76
Ventral brain stem	0.72–1.27	0.93 ± 0.13	0.92
Dorsal brain stem	0.74–1.28	0.89 ± 0.10	0.90
Genu corpus callosum	0.64–1.35	0.98 ± 0.20	0.93
Splenium corpus callosum	0.65–1.71	0.86 ± 0.20	0.84
Anterior limb internal capsule	0.62–1.23	0.83 ± 0.12	0.82
Posterior limb internal capsule	0.65–0.99	0.81 ± 0.09	0.80
Corona radiate	0.71–1.01	0.86 ± 0.08	0.86
Centrum semiovale	0.72–1.43	0.95 ± 0.17	0.89

Table 3 Correlation between age and the measured ADC values.

	Age
	r	p
Middle cerebellar peduncle	−0.584^⁎	0.001
Ventral brain stem	−0.696^⁎	<0.001
Dorsal brain stem	−0.790^⁎	<0.001
Genu corpus callosum	−0.796^⁎	<0.001
Splenium corpus callosum	−0.469^⁎	0.009
Anterior limb internal capsule	−0.620^⁎	<0.001
Posterior limb internal capsule	−0.867^⁎	<0.001
Corona radiate	−0.771^⁎	<0.001
Centrum semiovale	−0.681^⁎	<0.001

r: Pearson coefficient.

⁎ Statistically significant at p ⩽ 0.05.

Figure 1 Correlation between age (by months) and ADC value in middle cerebellar peduncle. The restriction appeared at age of 3 months with significant decrease in the ADC values with progression of the age (p = 0.001).

Figure 2 Correlation between age (by months) and ADC value in dorsal brain stem. The restriction was present at age of 1 month with a significant decrease in the ADC values with progression of the age (p < 0.001).

Figure 3 Correlation between age and ADC value in ventral brain stem. The restriction appeared at age of 6 months in some of the cases and at the age of 7 months in other cases with a significant decrease in the ADC values with progression of the age (p < 0.001).

Figure 4 Correlation between age and ADC value in genu of the corpus callosum. The restriction appeared at age of 9 months with a significant decrease in the ADC values with progression of the age (p < 0.001).

Figure 5 Correlation between age and ADC value in splenium of the corpus callosum. The restriction appeared at age of 3 months with a significant decrease in the ADC values with increase the age (p = 0.009).

Figure 6 Correlation between age and ADC value in anterior limb internal capsule .The restriction appeared at age of a significant decrease in the ADC values with increase the age (p < 0.001).

Figure 7 Correlation between age (by months) and ADC value in posterior limb internal capsule. The restriction was present at age of 1 month with a significant decrease in the ADC value with increase the age (p < 0.001).

Figure 8 Correlation between age and ADC value in corona radiate. The restriction was present at age of 1 month with a significant decrease in the ADC values with increase the age (p < 0.001).

Figure 9 Correlation between age (by months) and ADC value in centrum semiovale .The restriction appeared at age ranging between 6 and 9 significant with a decrease in the ADC values with increase the age (p < 0.001).