Reduced glomerular filtration rate as a predictor of coronary artery disease events in elderly patients

Peer review under responsibility of Alexandria University Faculty of Medicine.

Available online 9 July 2016

Figures & data

Table 1 Baseline characteristics of all study population.

Patient Characteristics	eGFR ⩾ 60 (n = 410) (Group 1)	eGFR (40–60) n = (390) (Group 2)
Age	66 ± 6	69 ± 5
Gender M/F	200/210	341/49
Basal disease
Angina pectoris (n = 223)	110	113
Old myocardial infarction (n = 168)	77	91
Ischemic cardiopathy (n = 70)	29	41
No CAD (n = 339)	194	145
Risk factor
Hypertension	127	176
Diabetes mellitus	41	51
Dyslipidemia	180	203

Table 2 Laboratory, clinical and demographic characteristics in both groups according to eGFR.

	Group 1 (eGFR ⩾ 60)	Group 2 (eGFR 40–60)	P value
Age	66 ± 7	69 ± 5	<0.001
Male	200 (48.8%)	341 (87.4%)	0.08
CAD patients	215 (52.4%)	259 (66%)	<0.001
Dyslipidemia	180 (44%)	203 (52%)	0.42
Diabetes	41 (10%)	51 (13%)	<0.001
Hypertension	127 (31%)	176 (45%)	<0.001
BMI (kg/m^2)	25.5 ± 3.8	25.8 ± 3.5	0.15
TG (mg/dL)	150 ± 99	145 ± 85	0.52
LDL cholesterol (mg/dL)	101 ± 22	98 ± 25	0.08
HDL cholesterol (mg/dL)	48 ± 12	45 ± 11	<0.001

Table 3 Comparison of those with and without CAD.

	All participants n = 800	CAD n = 461	No CAD n = 339	P value
Age	65 ± 9	69 ± 2	65 ± 4	<0.001
Hypertension	303 (37.8%)	212 (70%)	91 (30%)	<0.001
eGFR	75.2 ± 14	62 ± 13	76 ± 11	<0.001

Table 4 Relation of risk factors with eGFR levels (mL/min/1.73 m²) in males and females.

Variable	Male (eGFR(mL/min/1.73 m^2))			Female (eGFR(mL/min/1.73 m^2))
	⩾60 (n = 200)	40–60 (n = 341)	P value	⩾60 (n = 210)	40–60 (n = 49)	P value
Diabetes	19 (9.5%)	41 (12%)	<0.001	22 (10.47%)	10 (20.4%)	<0.001
Hypertension	90 (45%)	167 (48.9%)	0.32	37 (17.6%)	9 (18.4%)	0.21
BMI ⩾ 25 (kg/m^2)	100 (50%)	177 (51.9%)	0.51	131 (62.3%)	32 (65.3%)	<0.05
TG ⩾ 197.2 (mg/dL)	120 (60%)	219 (64.2%)	0.01	123 (58.5%)	30 (61.2%)	0.02
LDL cholesterol ⩾ 130.3 (mg/dL)	30 (15%)	72 (21.1%)	<0.001	42 (20%)	12 (24.4%)	<0.001
HDL < 40.2 (mg/dL)	33 (16.5%)	77 (22.5%)	<0.001	21 (10%)	8 (16.3)	<0.001