Subclinical hypothyroidism ups the risk of vascular complications in type 2 diabetes

Peer review under responsibility of Alexandria University Faculty of Medicine.

Available online 31 December 2016

Figures & data

Figure 1 The prevalence of vascular complications in type 2 diabetes patients with and without subclinical hypothyroidism (SCH).

Table 1 Comparison between the participants with Euthyroid and SCH in type 2 diabetic patients regarding the different clinical parameters.

	Euthyroid (n = 89)	SCH (n = 21)	P value
Age (years)	57.78 ± 11.045	63.43 ± 6.95	0.027
Sex (M/F)	40/49	5/16	0.076
Duration of DM(years)	16.64 ± 10.245	22.10 ± 7.77	0.007
BMI (kg/m^2)	31.27 ± 6.19	34.2143 ± 7.36	0.092
HbA1c (%)	8.17 ± 1.72	9.15 ± 1.78	0.025
Total cholesterol (mmol/l)	3.85 ± 0.79	5.05 ± 0.83	<0.001
Triglycerides (TG) (mmol/l)	1.54 ± 0.81	1.57 ± 0.50	0.322
LDL cholesterol (mmol/l)	1.89 ± 0.61	2.93 ± 0.73	<0.001
HDL cholesterol (mmol/l)	1.17 ± 0.39	1.41 ± 0.27	0.001
TSH (mU/l)	2.24 ± 0.74	6.37 ± 1.88	<0.001
T4 (pmol/l)	15.49 ± 2.11	14.38 ± 1.66	0.027
UAE	126.43 ± 303.67	434.63 ± 546.92	0.011
Dyslipidemia (%)	97.8	85.7	0.017
HTN (%)	76.4	66.7	0.357
Smoking (%)	24.7	28.6	0.715

Table 2 The prevalence of vascular complications in type 2 diabetic patients with and without SCH.

	Euthyroid (n = 89)	SCH (n = 21)	P value
Retinopathy (%)	32.6	66.7	0.004
Nephropathy (%)	36	71.4	0.003
Neuropathy (%)	24.7	33.3	0.420
IHD (%)	28.1	57.1	0.011