The possible protective effect of lactoferrin on lipopolysaccharide-induced memory impairment in albino rats

Peer review under responsibility of Alexandria University Faculty of Medicine.

Figures & data

Table 1 Effect of LF on first day latency and retention latency of PA test in albino rats.

Parameters	Control group	LPS-group	LF-group
First day latency (sec)	42.2 ± 4.61	45.0 ± 3.80	46.5 ± 3.69
Retention latency (sec)	261.0 ± 27.57	46.10 ± 4.43^a	244.4 ± 25.43^b

Data are given as mean ± SD.

a P < 0.05 vs control group.

b P < 0.05 vs LPS-group.

Fig. 1 Effect of LF on brain levels of MDA and GSH in albino rats. Data are given as mean ± SD. ^aP < 0.05 vs control group, ^bP < 0.05 vs LPS-group.

Table 2 Effect of LF on brain levels of TNF-α, IL-1β, and NF-κB, in albino rats.

Parameters	Control group	LF-group	LF-group
TNF- (pg/mg protein)	131.20 ± 10.78	471.20 ± 15.63^a	269.10 ± 15.24^a,b
IL-1 (pg/mg protein)	41.10 ± 6.42	255.0 ± 30.33^a	157.80 ± 15.78^a,b
NF-κB (ng/mg protein)	79.70 ± 7.93	375.70 ± 17.12^a	295.50 ± 11.38^a,b

Data are given as mean ± SD.

a P < 0.05 vs control group.

b P < 0.05 vs LPS-group.

Fig. 2 Effect of LF on brain levels of BDNF and acetylcholinestrase activity in albino rats. Data are given as mean ± SD. ^aP < 0.05 vs control group, ^bP < 0.05 vs LPS-group.