Efficacy and safety of tamsulosin oral-controlled absorption system, solifenacin, and combined therapy for the management of ureteric stent-related symptoms

Peer review under responsibility of Arab Association of Urology.

Figures & data

Figure 1 Participants flow diagram.

Table 1 The patients’ characteristics in studied groups.

Variable	Group I	Group II	Group III	Group IV	Total	P
	Control	Tamsulosin OCAS	Solifenacin	Solifenacin + tamsulosin OCAS
Number of patients	56	59	58	61	234
Age, years Mean (SD, range)	39.6 (12.6, 22–79)	37.2 (11.8,22–68)	41.9 (10.3, 23–69)	38.9 (9.4,22–62)	39.4 (11.1,22–79)	0.138
N (%)
Gender						0.989
Male	35 (62.5)	35 (59)	35 (60)	37 (61)	142 (61)
female	21 (37.5)	24 (41)	23 (40)	24 (39)	92 (39)
Indications						0.624
URSL	18 (32)	26 (44)	24 (41)	31 (51)	99 (42)
ESWL	21 (37)	13 (22)	15 (26)	13 (21)	62 (27)
PCNL	10 (18)	11 (19)	11 (19)	13 (21)	45 (19)
Stricture ureter	5 (9)	6 (10)	6 (11)	4 (7)	21 (9)
Endopyelotomy	2 (4)	3 (5)	2 (3)	0	7 (3)
Laterality						0.713
Right	28 (50)	27 (46)	26 (45)	24 (39)	105 (45)
left	28 (50)	32 (54)	32 (55)	37 (61)	129 (55)
JJ stent diameter, F						0.429
4.7	18 (32)	15 (25)	24 (41)	24 (39)	81 (35)
6	22 (39)	24 (41)	22 (38)	25 (41)	93 (40)
7	16 (29)	20 (34)	12 (21)	12 (20)	60 (25)
JJ stent length, cm						0.435
24	5 (9)	10 (17)	13 (22)	14 (23)	42 (18)
26	34 (61)	31 (52)	31 (54)	34 (56)	130 (56)
28	17 (30)	18 (31)	14 (24)	13 (21)	62 (26)
JJ stent proximal curl						0.897
Complete	55 (98)	57 (97)	57 (98)	60 (98)	229 (98)
Incomplete	1 (2)	2 (3)	1 (2)	1 (2)	5 (2)
JJ stent distal curl
Complete	56	59	58	61	234 (100)
JJ stent crossing midline						0.156
Not crossing	41 (73)	45 (76)	35 (60)	47 (77)	168 (72)
Crossing	15 (27)	14 (24)	23 (40)	14 (23)	66 (28)

Table 2 Mean (SD, range) USSQ domain scores in the four studied groups.

USSQ domains		Group I	Group II	Group III	Group IV
		Control (n = 56)	Tamsulosin (n = 59)	Solifenacin (n = 58)	Solifenacin + tamsulosin OCAS (n = 61)
Urinary symptoms		37.1 (3.1, 30–44)	22.9 (2.4, 19–30)	22 (2.8, 18–32)	16.6 (2.5, 14–23)
	P^∗		<0.001	<0.001	<0.001
	P^∗∗			0.074
	P^∗∗∗		<0.001	<0.001
Body pain		21.3 (5, 8–31)	15.3 (7.3, 6–24)	15.5 (5.5, 6–23)	10.7 (4.8, 6–18)
	P^∗		<0.001	<0.001	<0.001
	P^∗∗			0.842
	P^∗∗∗		<0.001	<0.001
General health		17.3 (4.5, 7–26)	12.5 (5.4, 7–25)	12.8 (4.1, 7–24)	10.4 (3.4, 7–16)
	P^∗		<0.001	<0.001	<0.001
	P^∗∗			0.695
	P^∗∗∗		0.008	0.002
Work performance		13 (2.5, 9–18)	10.7 (2.3, 7–16)	10.9 (2.1, 7–15)	9.7 (1.9, 7–14)
	P^∗		<0.001	<0.001	<0.001
	P^∗∗			0.561
	P^∗∗∗		0.009	0.002
Sexual matters		9.8 (8.1, 0–19)	5.2 (7.2, 0–19)	5.5 (7.6, 0–19)	2.4 (2.3, 0–6)
	P^∗		<0.001	0.001	<0.001
	P^∗∗			0.820
	P^∗∗∗		0.019	0.011
Other problems		8.8 (2, 8–15)	8.1 (1.2, 7–12)	7.9 (1.1, 7–12)	7.9 (1.3, 7–12)
	P^∗		0.009	0.001	0.001
	P^∗∗			0.520
	P^∗∗∗		0.523	0.990
Total score		107.4 (19.7, 67–147)	74.8 (20.8, 48–118)	74.7 (16.7, 48–119)	57.7 (10.3, 41–78)
	P^∗		<0.001	<0.001	<0.001
	P^∗∗			0.995
	P^∗∗∗		<0.001	<0.001

P^∗, P value vs control; P^∗∗, P value group II vs group III; P^∗∗∗, P value vs Group IV (combination). ANOVA test and post hoc Dunnett’s t-test.

Figure 2 Mean USSQ domain scores in the studied groups.

Table 3 Spearman’s rho correlation coefficient in 178 medicated patients with different JJ stent variables.

JJ stent variables		Urinary symptoms	Body pain	General health	Work performance	Sexual matters	Other problems	Total score
Diameter	Correlation coefficient	0.157	0.047	0.086	0.037	−0.033	0.374	0.095
	P	0.037	0.533	0.256	0.624	0.666	<0.001	0.206
Length	Correlation coefficient	0.110	0.116	0.185	0.106	0.181	0.181	0.167
	P	0.142	0.124	0.014	0.159	0.016	0.016	0.026
Crossing midline	Correlation coefficient	0.253	0.306	0.385	0.231	0.140	0.323	0.366
	P	0.001	<0.001	<0.001	0.002	0.063	<0.001	<0.001

Table 4 Mean (SD) USSQ domain scores associated with JJ stent distal curl position in relation to midline among the medicated groups.

USSQ domain	Not crossing midline n = 127	Crossing midline n = 51	P ^∗
Urinary symptoms	19.9 (3.7)	21.9 (3.7)	0.001
Body pain	12.5 (6.3)	16.8 (5.3)	<0.001
General health	10.7 (3.6)	14.9 (5.1)	<0.001
Work performance	10.1 (2.1)	11.3 (2.1)	0.001
Sexual matters	3.3 (4.8)	7 (8.3)	<0.001
Other problems	7.7 (0.7)	8.8 (1.7)	<0.001
Total score	64.1 (14.8)	80.7 (20.7)	<0.001

∗ Student’s t-test for independent samples.