Innovative trends and perspectives for erectile dysfunction treatment: A systematic review

Peer review under responsibility of Arab Association of Urology.

Figures & data

Table 1 Innovative trends in treatment of ED.

I. Phosphodiesterase type 5 inhibitors (PDE5Is)

a. Novel PDE5Is

b. Tadalafil once-daily

c. PDE5Is for LUTS

II. Soluble guanylate cyclase (sGC) activators

a. BAY 60-2770

b. BAY 41-2272

III. Herbal treatment

a. Herbal combinations

b. Resveratrol

c. Pyrazolopyrimidinone analogues

d. Neuromedin B

IV. Stem cells

a. Adipose tissue-derived stem cells (ADSCs)

b. human umbilical cord blood mesenchymal stem cells (hUCB-MSCs)

c. Bone marrow-derived stem cell

d. MSCs and muscle-derived stem cells

e. Combined stem cell and shockwave therapy

V. Low-intensity extracorporeal shockwave therapy (LI-ESWT)

a. The underlying mechanisms of how LI-ESWT improves erection

b. Limitations of LI-ESWT

VI. Vacuum erection device (VED)

VII. External penile support devices

VIII. Penile vibrators

IX. Impulse magnetic-field therapy

X. Tissue engineering

XI. Nanotechnology

XII. Endovascular tools