Prophylactic multimodal antiemetic in women undergoing cesarean section under spinal anesthesia

Available online 13 May 2011

Figures & data

Table 1 Patients characteristics and intraoperative data.

	I	II	III
Age (yr)	26.5 ± 3.6	24.4  ± 2.1	23.4  ± 2.7
Weight (kg)	78  ± 3.2	77  ± 4.1	79  ± 4.1
Height (cm)	167.1  ± 3.4	168.2  ± 3.1	169.2  ± 1.4
Gestational age (weeks)	38.7  ± 1.7	38.9  ± 1.6	38.8  ± 1.9
Surgery duration (min)	72.1  ± 2.8	73.3  ± 1.2	74.3  ± 2.2
Phenylephrine dose (μg)	235  ± 3.2	229 ± 3.2	224 ± 4.1
Sensory block (median, range)	T4 (T2–T6)	T4 (T2–T5)	T4 (T1–T5)

Data are presented as mean ± standard deviation or median (range).

I = Control group, II = granisetron dexamethasone group, III = midazolam dexamethasone group.

P value < 0.05 is significant.

This table shows no significant differences.

Figure 1 Intraoperative mean arterial blood pressure (mm Hg) of the studied groups.

Figure 2 Intraoperative heart rate of the studied groups. All Groups were statistically comparable.

Table 2 Incidence of nausea and vomiting.

Variable	Group I	Group II	Group III
Intraoperative period
Predelivery nausea	17 (21%)	15 (19%)	16 (20%)
Predelivery vomiting	20 (25%)	21 (26%)	18 (22%)
Postdelivery nausea	16 (20%)	7 (9%)^a	11 (14%)^a^,^b
Postdelivery vomiting	19 (23%)	6 (8%)^a	12 (15%)^a^,^b
Rescue antiemetic	30 (37%)	11 (14%)^a	19 (23%)^a^,^b
Sedation score	0 (0-0)	0 (0-0)	1 (1–2)^a^,^b
Postoperative period
Nausea(0–24 h)	25 (31%)	6 (8%)^a	11 (14%)^a^,^b
Vomiting (0–24 h)	18 (22%)	5 (6%)^a	9 (11%)^a^,^b
Rescue antiemetic	20 (25%)	7 (9%)^a	13 (16%)^a^,^b
Sedation score	0 (0–0)	0 (0–0)	0 (0–1)

Values are presented as number of patient (percentage of study group) or median (range).

P value < 0.05 is significant.

a Significant when compared to group I.

b Significant when compared to group II.

Table 3 Patient satisfaction and side effects.

	I	II	II
Patient satisfaction score	5.6 ± 1.4^b	8.3  ± 1.2^a	8.1 ± 2.3^a
Headache	4	3	4
Drowsiness	2	1	1
Facial flushing	3	2	2
Bradycardia	3	4	4

Values are presented as number of patients or mean ± standard deviation.

P value < 0.05 is significant.

a Significant when compared to group I.

b Significant when compared to group II.