The efficacy of preoperative pregabalin on reduction of the incidence and severity of postdural puncture headache after spinal anesthesia

Peer review under responsibility of Egyptian Society of Anesthesiologists.

Figures & data

Figure 1 Postoperative VAS of pain in the studied groups Group (C):control group, Group (P): pregabalin group.

Table 1 Demographic characteristics of patients in the study groups. Data were expressed as mean ± SD and numbers.

	Group (C n = 43)	Group (P n = 43)
Age (year)	29.6 ± 6.5	28 ± 6.8
Weight (kg)	75.4 ± 7.9	77.1 ± 7.4
Sex (male/female)	25/18	27/16
Height (cm)	170.1 ± 10.2	167.8 ± 8.4
Duration of surgery (min)	145.2 ± 2.6	139.6 ± 7.6

Group (C): control group.

Group (P): pregabalin group.

Table 2 Spinal block characteristics (onset and regression time of sensory and motor blocks in minutes). Data were expressed as mean ± SD.

	Group (C n = 43)	Group (P n = 43)	p Value
Peak sensory block level	T6(6–8)	T7(5–8)
Time to Peak sensory block (min)	10.8 ± 1.7	7.6 ± 1.2	0.05
Time to two segment regression (min)	72.2 ± 7.1	74.3 ± 1.4
Onset time to modified Bromage 3 (min)	13.6 ± 2.4	11.4 ± 2.8	0.02
Regression to modified Bromage 0 (min)	144.6 ± 14.2	150.1 ± 15.8
Time to rescue analgesia (min)	225.6 ± 35.1	248.6 ± 57.8	0.04

Group (C): control group.

Group (P): pregabalin group.

p ⩽ 0.05 Statistically significance.

Table 3 PDPH characters (incidence rate, intensity classes, time of onset (day), and number of needle attempts). Data were expressed in number with or without (%).

	Group (C n = 43)	Group (P n = 43)	p Value
Incidence of headache	13(30%)	7(16%)	0.02
Classes of headache
Class I	3(23%)	4(57%)
Class II	4(31%)	2(29%)
Class III	6(46%)	1(14%)	0.008
Onset day of headache
Fist day	0	0
Second day	9	5
Third day	4	2
Number of spinal needle punctures
One attempt	37	35
Two attempts	6	8

Group (C): control group.

Group (P): pregabalin group.

p ⩽ 0.05 statistically significance.

Figure 2 Postoperative sedation score in the studied groups (C): control group, Group (P): pregabalin group.