Comparative study between effect of carbetocin and oxytocin on isoflurane-induced uterine hypotonia in twin pregnancy patients undergoing cesarean section

Peer review under responsibility of Egyptian Society of Anesthesiologists.

Figures & data

igure 1 Heart rate values. Group C: Those patients who received carbetocin. Group O: Those patients who received oxytocin.

able 1 Patient characteristics:

	Group (C) (n = 30)	Group (O) (n = 30)	p-Value
Age (yr)	25.4 ± 4	24.5 ± 3	0.24
BMI (kg/m^2)	25.6 ± 2.7	26 ± 2.8	0.6
Parity	3(2–4)	4(3–5)	0.07
Hemoglobin (gm%)	10 ± 0.9	9.8 ± 0.7	0.068
Previous C.S.	2(1–3)	2(2–2)	0.2
Duration of surgery (min)	33.8 ± 2.7	34 ± 3	0.79
Birth weight (kg)	2.4 ± 0.34	3 ± 0.3	0.2

Group C: Those patients who received carbetocin.

Group O: Those patients who received oxytocin.

Values are expressed as mean ± SD or median (IQR).

p > 0.05 was considered statistically nonsignificant.

able 2 Mean heart rate values in two study groups.

Time (min)	Group C (n = 30)	Group O (n = 30)	p value
0 (baseline)	76.2 ± 5.16	75.9 ± 4.9	0.83
HR 5 min	84.3 ± 3.1	83.1 ± 2.4	0.07
HR 10 min	83.3 ± 3.09	82.8 ± 2.7	0.058
HR 15 min	84.5 ± 2.74	84.1 ± 3	0.6
HR 20 min	81 ± 3.5	84.5 ± 3	0.08
HR 25 min	78.9 ± 3.1	84.8 ± 3^⁎	<0.001
HR 30 min	76.3 ± 1.8	82.5 ± 3.4^⁎	0.023
HR 35 min	75.6 ± 2.8	80 ± 3.4^⁎	<0.001
HR 40 min	74.2 ± 3.1	80 ± 2^⁎	<0.001
HR 50 min	76.8 ± 3.6	79 ± 3^⁎	0.03
HR 60 min	78.7 ± 2.8	79.4 ± 2.4	0.29

Group C: Those patients who received carbetocin.

Group O: Those patients who received oxytocin.

Values are expressed as mean ± SD.

#x204E; p < 0.05 was considered statistically significant between the 2 groups.

able 3 Mean arterial blood pressure.

Time	Group C (n = 30)	Group O (n = 30)	p value
Baseline MABP	71 ± 6.3	72.1 ± 4.8	0.44
MABP 5 min	69.6 ± 3.6	70 ± 3.4	0.8
MABP 10 min	75.8 ± 2.7	74.3 ± 4	0.08
MABP 15 min	75.2 ± 2.8	71 ± 2.3	0.068
MABP 20 min	75 ± 2.6	70 ± 3.8^⁎	0.003
MABP 25 min	74 ± 2.4	68.7 ± 3^⁎	0.005
MABP 30 min	73.6 ± 2.4	68.8 ± 2.3^⁎	0.004
MABP 35 min	73 ± 2.4	69.4 ± 5^⁎	0.004
MABP 40 min	74 ± 1.8	69.3 ± 4.8^⁎	<0.001
MABP 50 min	75 ± 4.7	70.5 ± 3.7^⁎	0.03
MABP 60 min	74.4 ± 5	70.6 ± 2.2	0.068

Group C: Those patients who received carbetocin.

Group O: Those patients who received oxytocin.

Data are presented as mean ± SD.

#x204E; p < 0.05 was considered statistically significant.

able 4 Uterine contraction score.

Time	Group C (n = 30)	Group O (n = 30)	p-Value
Uterine tone 2 min	3(2–3)^⁎	2(1–2)	<0.001
Uterine tone 2 h	3(2–3)^⁎	2(2–3)	<0.001

Group C: Those who received carbetocin.

Group O: Those who received oxytocin.

Values are expressed as median (range).

#x204E; p < 0.001 was considered statistically significant.

able 5 Number of patients with unsatisfactory uterine tone.

Time	Group C (n = 30)	Group O (n = 30)	p-Value
Number of patients with reduced isoflurane concentration	5(16.7%)	15(50%)	<0.001
Number of patients who need methergine	4(13.3%)	15(50%) one dose	<0.001
		10(33.3%) 2 doses
Number of patients who need blood transfusion	1(3.33%)	4(13.3%)	<0.001
Blood loss (ml)	437 ± 45	721 ± 50	<0.001

Group C: Those who received carbetocin.

Group O: Those who received oxytocin.

Data are presented as number and percentage of patients or mean (SD).