Attenuation of hemodynamic response to laryngoscopy and endotracheal intubation with two different doses of labetalol in hypertensive patients

Peer review under responsibility of Egyptian Society of Anesthesiologists.

Figures & data

able 1 Demographic data.

	Group L1 (n = 25)	Group L2 (n = 25)	Group C (n = 25)
Age (yr)	42 ± 10	41 ± 12	42 ± 12
Sex (female/male)	18/7	19/6	19/6
Height (cm)	155 ± 10	156 ± 12	154 ± 11
Weight (kg)	52 ± 10	51 ± 11	50 ± 11
Antihypertensive medication
#x2013; Calcium channel blocker	13	10	11
#x2013; Renin-angiotensin inhibitor	12	15	14

Mean values ± SD or number. L1 = labetalol (0.15 mg/kg), L2 = labetalol (0.3 mg/kg) C = control.

able 2 Heart rate.

HR	Group C	Group L1	Group L2	P value C & L1	P value C & L2	P value L2 & L1
Pre-induction	83.64 ± 6.0	82.44 ± 6.3	84.24 ± 6.4	(P > 0.05)	(P > 0.05)	(P > 0.05)
At intubation	109.40 ± 6.3	96.20 ± 7.0	93.72 ± 5.6	P < 0.001	P < 0.001	(P > 0.05)
I min post-intubation	104.20 ± 6.1	96.24 ± 6.5	94.40 ± 5.2	P < 0.001	P < 0.001	(P > 0.05)
3 min post-intubation	93.64 ± 4.4	88.08 ± 6.2	86.68 ± 5.3	P < 0.001	P < 0.001	(P > 0.05)
5 min post-intubation	86.36 ± 3.4	81.60 ± 6.3	75.04 ± 10.9	P < 0.001	P < 0.001	P < 0.001
10 min post-intubation	78.60 ± 4.5	72.16 ± 6.8	69.04 ± 9.9	P < 0.001	P < 0.001	(P > 0.05)

Mean value ± SD.

able 3 Systolic blood pressure.

SBP	Group C	Group L1	Group L2	P value C & L1	P value C & L2	P value L2 & L1
Pre-induction	132 ± 5.5	131.44 ± 1.5	133.04 ± 5.0	(P > 0.05)	(P > 0.05)	(P > 0.05)
At intubation	162.16 ± 13.0	145.88 ± 6.7	144.88 ± 6.0	P < 0.001	P < 0.001	(P > 0.05)
I min post intubation	152.72 ± 12.0	139.96 ± 5.4	136.80 ± 5.8	P < 0.001	P < 0.001	(P > 0.05)
3 min post-intubation	140.92 ± 8.3	131.68 ± 5.2	121.80 ± 9.4	P < 0.001	P < 0.001	P < 0.001
5 min post-intubation	136.28 ± 5.6	123.24 ± 8.6	111.92 ± 11.6	P < 0.001	P < 0.001	P < 0.001
10 min post-intubation	129.64 ± 6.6	111.60 ± 8.2	104.20 ± 7.0	P < 0.001	P < 0.001	P < 0.001

Mean value ± SD.

able 4 Diastolic blood pressure.

DBP	Group C	Group L1	Group L2	P value C & L1	P value C & L2	P value L2 & L1
Pre-induction	82.60 ± 5.2	82.40 ± 5.0	81.72 ± 4.9	(P > 0.05)	(P > 0.05)	(P > 0.05)
At intubation	102.56 ± 3.8	93.0 ± 5.1	91.0 ± 5.2	P < 0.001	P < 0.001	(P > 0.05)
I min post-intubation	104.40 ± 7.9	89.48 ± 8.4	86.40 ± 11.4	P < 0.001	P < 0.001	(P > 0.05)
3 min post-intubation	114.01 ± 4.1	100.56 ± 86.8	93.21 ± 7.0	P < 0.001	P < 0.001	P < 0.001
5 min post-intubation	94.28 ± 5.6	81.88 ± 4.4	71.36 ± 9.3	P < 0.001	P < 0.001	P < 0.001
10 min post-intubation	82.20 ± 7.5	72.84 ± 5.2	67.88 ± 7.5	P < 0.001	P < 0.001	P < 0.001

Mean value ± SD.

able 5 Mean arterial pressure.

MAP	Group C	Group L1	Group L2	P value C & L1	P value C & L2	P value L2 & L1
Pre-induction	99.25 ± 4.6	98.75 ± 4.5	98.83 ± 4.4	(P > 0.05)	(P > 0.05)	(P > 0.05)
At intubation	122.43 ± 6.0	110.63 ± 4.9	108.96 ± 4.4	P < 0.001	P < 0.001	(P > 0.05)
I min post-intubation	120.51 ± 7.6	106.31 ± 5.4	103.20 ± 8.4	P < 0.001	P < 0.001	(P > 0.05)
3 min post-intubation	114.01 ± 4.1	100.19 ± 8.6	93.21 ± 7.0	P < 0.001	P < 0.001	P < 0.001
5 min post-intubation	108.28 ± 4.7	95.67 ± 4.0	84.88 ± 8.8	P < 0.001	P < 0.001	P < 0.001
10 min post-intubation	98.00 ± 6.0	85.64 ± 4.4	80.00 ± 6.3	P < 0.001	P < 0.001	P < 0.001

Mean value ± SD.

able 6 Rate pressure product (RPP).

RPP	Group C	Group L1	Group L2	P value C & L1	P value C & L2	P value L2 & L1
Pre-induction	11097.12 ± 993.9	10835.12 ± 921.5	11200.88 ± 878.0	(P > 0.05)	(P > 0.05)	(P > 0.05)
At intubation	17756.48 ± 1948.2	14037.28 ± 1279.0	13571.20 ± 895.4	P < 0.001	P < 0.001	(P > 0.05)
I min post-intubation	15936.16 ± 1766.5	3455.92 ± 861.94	12911.20 ± 875.3	P < 0.001	P < 0.001	(P > 0.05)
3 min post-intubation	13210.44 ± 1179.0	11596.32 ± 927.3	10565.44 ± 1116.9	P < 0.001	P < 0.001	P < 0.001
5 min post-intubation	11771.36 ± 717.7	10062.40 ± 1125.8	8481.20 ± 1787.5	P < 0.001	P < 0.001	P < 0.001
10 min post-intubation	10185.04 ± 741.1	8054.24 ± 974.4	7219.68 ± 1290.5	P < 0.001	P < 0.001	P < 0.001

Mean value ± SD.