Multimodal analgesia with pregabalin and dexmedetomidine in morbidly obese patients undergoing laparoscopic sleeve gastrectomy: A prospective randomized double blind placebo controlled study

Peer review under responsibility of Egyptian Society of Anesthesiologists.

Figures & data

igure 1 Flow diagram of participants.

igure 2 Trends of heart rate, data are presented as mean and standard deviation, ∗ statistically significant lower HR in group A compared to group B (p < 0.05), HR: heart rate.

igure 3 Trends of mean arterial blood pressure, data are presented as mean and standard deviation, ∗ statistically significant lower MAP in group A compared to group B (p < 0.05), MAP: mean arterial pressure.

able 1 Patients’ characteristics and duration of surgery.

Parameters	Group A (n = 30)	Group B (n = 30)	P value
Age (years)	33.80 ± 8.84	33.93 ± 9.14	0.954
BMI (kg/m^2)	49.33 ± 3.30	48.77 ± 3.41	0.516
Gender M/F	13/17	11/19	0.598
Duration of surgery (minutes)	117.77 ± 5.98	117.87 ± 6.54	0.951

Data are expressed as mean ± standard deviation or count; BMI: body mass index, M: male, F: female.

igure 4 Ramsay sedation score, data are presented as mean and standard deviation, ∗ statistically significant higher sedation scores in group A compared to group B (p < 0.05).

igure 5 Visual analogue scale, data are presented as mean and standard deviation, ∗ statistically significant lower VAS in group A compared to group B (p < 0.05), VAS: Visual analogue scale.

igure 6 Nausea verbal rating scale, data are presented as mean and standard deviation, ∗ statistically significant lower nausea verbal rating scale in group A compared to group B (p < 0.05), VRS: verbal rating scale.

able 2 Narcotic consumption.

Parameters	Group A (n = 30)	Group B (n = 30)	P value
Intraoperative fentanyl consumption (μg)	134.17 ± 36.84	254.17 ± 42.59	<0.001^⁎
Postoperative morphine consumption (mg)	15.07 ± 2.65	45.93 ± 4.56	<0.001^⁎

Data are presented as mean and standard deviation.

#x204E; Statistically significant lower narcotic consumption in group A compared to group B (p < 0.05).