Impact of single dose intravenous tranexamic acid on peri-operative blood transfusion requirements in burn patients: A prospective, randomized trial

Peer review under responsibility of Egyptian Society of Anesthesiologists.

Figures & data

Fig. 1 Consort flow diagram.

Table 1 Demographic characteristics of patients.

	Tranexamic group (n = 25)	Placebo group (n = 25)
Age (years)	35.12 ± 8.65	36.16 ± 9.22
Weight (kg)	59.36 ± 7.12	60.28 ± 7.50
BMI (kg/m^2)	20.8 ± 1.7	21.6 ± 1.9
BSA (m^2)	1.7 ± 0.5	1.8 ± 0.6
Gender (M/F)	15/10	14/11
Patient temperature (°F)	98.6 ± 1.2	98.1 ± 1.4
Duration of surgery (min)	101.80 ± 20.15	104.00 ± 19.69
Total Burn Surface Area (%)	38.64 ± 7.13	41.80 ± 6.60
Patients undergoing limb debridement (number)	13	11
	(– Only limb burns in variable combinations = 7 – limb burns with minor trunk involvement = 6)	(– Only limb burns in variable combinations = 6 – limb burns with minor trunk involvement = 5)
Patients undergoing mainly trunk debridement (number)	12	14

Values are expressed as mean ± SD or number.

Table 2 Intraoperative blood loss in both groups.

	Tranexamic group (n = 25)	Placebo group (n = 25)	p-values
Blood loss/total burn surface area (ml/%burn surface area)	14.81 ± 7.73	23.78 ± 8.69	p < 0.0001

Values are expressed as mean ± SD.

Table 3 Preoperative hematologic data.

	Tranexamic group (n = 25)	Placebo group (n = 25)	p-values
Hemoglobin (g/dL)	10.34 ± 0.96	10.50 ± 0.95	0.545
Hematocrit (%)	31.72 ± 2.89	31.80 ± 2.77	0.829

Values are expressed as mean ± SD.

Table 4 Postoperative hematologic data.

	Tranexamic group (n = 25)	Placebo group (n = 25)	p-values
Hemoglobin (postoperative) (g/dL)	8.64 ± 1.30	7.69 ± 1.22	0.015
Hemoglobin (24 h postoperative) (g/dL)	8.28 ± 1.37	7.48 ± 1.07	0.040
Hematocrit (postoperative) (%)	26.08 ± 4.27	22.88 ± 3.77	0.010
Hematocrit 24 h (postoperative) (%)	24.68 ± 4.46	22.36 ± 3.32	0.068

Values are expressed as mean ± SD.

Table 5 Perioperative replacement solutions used in both groups.

	Tranexamic group (n = 25)	Placebo group (n = 25)	p-values
Intraop crystalloids (units)	3.00 ± 0.58	3.08 ± 0.49	0.605
Intraop colloids (units)	0.60 ± 0.65	1.32 ± 0.75	0.001
Total PRBC transfused (units)	0.28 ± 0.54	0.80 ± 0.87	0.022

Values are expressed as mean ± SD.