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Full Length Article

Volumetric and optical properties of ACE inhibitor captopril in aqueous-alcoholic mixturesFootnote

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Pages 815-821 | Received 25 Oct 2016, Accepted 23 Feb 2017, Published online: 16 Apr 2018

Figures & data

Table 1 Density, ρ (g cm−3) and refractive index data for CPT in pure solvents at 26 °C.

Table 2 Density, ρ (g cm−3) and refractive index data for CPT in aqueous-alcoholic mixtures at 26 °C.

Fig. 1 Hydrophilic, hydrophobic and hydrogen bonding sites in CPT.

Fig. 2 Plots of φv (cm3 mol−1) as a function of drug concentration in different pure solvents.

Fig. 3 Plots of φv (cm3 mol−1) as a function of drug concentration in different solvent mixtures.

Table 3 The φov (cm3 mol−1), Sv (cm3 dm3/2 mol−3/2) and transfer volumes, Δtrφ0v (cm3 mol−1) of CPT in pure solvents and aqueous-alcoholic mixtures.

Fig. 4 Plot of φ0v (cm3 mol−1) vs. vol % of alcohol content in different systems.

Table 4 Graphical parameters of concentration dependence of n, {n = K (dm3 mol−1) × c (mol dm−3) + n0} for CPT in pure solvents and aqueous-alcoholic mixtures.