Identification and evolutionary dynamics of two novel human coronavirus OC43 genotypes associated with acute respiratory infections: phylogenetic, spatiotemporal and transmission network analyses

Figures & data

Table 1 Demographic and clinical profile of patients infected with HCoV-OC43 lineages 1 and 2

Lineage	Strain ID	Collection date	Demographic profile		Symptoms reported
			Age	Sex
Lineage 1	MY-U208/12	28 March 2012	61	F	Sneezing, nasal discharge, sore throat, hoarseness of voice, cough
	MY-U413/12	2 May 2012	72	F	Nasal discharge
	MY-U464/12	9 May 2012	38	M	Nasal congestion, headache, sore throat, hoarseness of voice, cough
	MY-U523/12	18 May 2012	74	M	Sneezing, cough
	MY-U732/12	25 June 2012	53	F	Sneezing, nasal discharge, headache, cough
	MY-U868/12	16 July 2012	59	M	Nasal congestion, cough
	MY-U945/12	1 August 2012	11	M	Sneezing, nasal discharge, nasal congestion, headache
	MY-U1024/12	24 August 2012	61	F	Nasal congestion
	MY-U1140/12	10 September 2012	21	M	Sneezing, nasal discharge, sore throat, hoarseness of voice
Lineage 2	MY-U002/12	22 February 2012	71	F	Nasal congestion, headache, cough
	MY-U236/12	2 April 2012	19	M	Nasal discharge, nasal congestion, headache
	MY-U710/12	20 June 2012	50	F	Sneezing, nasal discharge, nasal congestion, cough
	MY-U774/12	2 July 2012	32	F	Sneezing, nasal congestion, headache, sore throat, hoarseness of voice, cough
	MY-U1057/12	27 August 2012	58	F	Sore throat, hoarseness of voice, cough
	MY-U1758/13	2 January 2013	56	M	Sneezing, nasal discharge, nasal congestion, headache, sore throat, cough
	MY-U1975/13	15 February 2013	52	F	Sneezing, headache, hoarseness of voice, cough

Abbreviations: Female, F; Male, M.

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Table 2 Time of most recent common ancestor (tMRCA) for HCoV-OC43 genotypes A to G estimated based on the spike (S) gene and full-length genome

Genotype	tMRCA (95% HPD)
	Spike (S) gene	Full-length genome
A	1963.8 (1959.4–1966.7)	1964.7 (1960.3–1966.8)
B	1999.1 (1996.6–2001.5)	1999.0 (1993.5–2002.6)
C	1997.2 (1994.0–1999.7)	1998.0 (1994.3–2000.5)
D	1997.3 (1994.2–2000.4)	1999.3 (1996.5–2001.5)
E	2007.9 (2005.9–2009.4)	2003.3 (1999.1–2006.9)
F	2010.8 (2010.0–2011.4)	2009.8 (2008.1–2011.2)
G	2010.7 (2010.0–2011.4)	2010.1 (2008.5–2011.4)

Abbreviation: highest posterior density, HPD.

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