Hepatitis C virus genotypes and subtypes circulating in Mainland China

Figures & data

Figure 1 Heatmap of hepatitis C virus (HCV) subtype percentages in 29 provinces. This heatmap was generated using R3.2.1 software. The maximum method was used in clustering analysis.

Figure 2 Hepatitis C virus (HCV) subtype distribution of males and females. Minor—minor subtypes; Mixed—mixed infections. The number of male carriers was much greater than females in this study, and male carriers showed a higher level of diversity. The Simpson’s diversity index of male and female carriers was 0.6688 and 0.5892 (P=1.23E−234), respectively.

Table 1 HCV genotyping and viral load

Figure 3 Composition of HCV genotype 1, 2, 3, 6 in Mainland China. (A) The distribution of HCV 1 in Mainland China. (B) The distribution of HCV 2 in Mainland China. (C) The distribution of HCV 3 in Mainland China. (D) The distribution of HCV 6 in mainland China. Data for three provinces were not shown because of the lack of positive cases (Xinjiang, Tibet, Beijing).

Table 2 Distribution of subtypes of HCV genotype 1, 2, and 3

Table 3 Distribution of HCV 6 subtypes

Provinces	Percentage of the rare subtypes of HCV genotype 6 (%)													n=
	6a	6n	6u	6	6g	6w	6v	6xa	6b	6e	6j	6q	6r
Central	100													239
Henan	100													13
Hubei	100													11
Hunan	100													215
East	86.7	10.7				1.3		1.3						75
Anhui	100													2
Fujian	87.5					6.3		6.3						16
Jiangsu	88.9	11.1												9
Jiangxi	100													13
Shandong	87.5	12.5												8
Shanghai	78.6	21.4												14
Zhejiang	76.9	23.1												13
North	94.4	5.6												18
Hebei	100													4
Inner-Mongolia	100													5
Shanxi	85.7	14.3												7
Tianjin	100													2
Northeast	92.7	7.3												41
Heilongjiang	100													4
Jilin	90.0	10.0												10
Liaoning	92.6	7.4												27
Northwest	92.9	3.6	1.2		1.2				1.2					84
Gansu	50.0				50.0									2
Ningxia	100													4
Shaanxi	93.6	3.8	1.3						1.3					78
South	99.1	0.3			0.2	0.2		0.1		0.1		0.1	0.1	1190
Guangdong	99.2	0.2				0.2		0.1		0.1		0.1	0.1	979
Guangxi	99.3	0.7												138
Hainan	97.3				2.7									73
Southwest	63.6	30.4	4.8	0.7			0.3				0.1			685
Chongqing	100													112
Guizhou	96.0	4.0												99
Sichuan	89.8	8.5	1.7											177
Yunnan	23.6	63.6	10.1	1.7			0.7				0.3			297
Total	87.99	9.69	1.46	0.21	0.13	0.13	0.09	0.09	0.04	0.04	0.04	0.04	0.04	2332