Hand transplantation

Figures & data

Table 1. Hand transplantations that have been performed worldwide

Date	Single-hand transplantation			Double-hand transplantation
Year, month	n	City	Reference	n	City	Reference
1998, IX	1	Lyon	Dubernard et al. 1999
1999, I	1	Louisville	Jones Jr. et al. 2000
1999, IX	2	Guangzhou	Pei et al. 2001
2000, I	2	Guangxi	www.handregistry.com	1	Lyon	Vallet et al. 2001
2000, III				1	Innsbruck	www.handregistry.com
2000, V	1	Kuala-Lumpur	Pathmanathan 2000
2000, IX				1	Guangzhou	Pei et al. 2001
2000, X	1	Milan	Lanzettà 2003
2001, I				1	Harbin	www.handregistry.com
2001, II	1	Louisville	Breidenbach III et al. 2002
2001, X	1	Milan	Lanzettá 2003
2002, VI	1	Bruxelles	www.handregistry.com
2002, XI	1	Milan	www.handregistry.com
2003, II				1	Innsbruck	www.handregistry.com
2003, V				1	Lyon	www.handregistry.com
Total no. of patients	12/18			6/18
Total no. of hands	12/24			12/24

Table 2. The first composite tissue allotransplantations performed (excluding hand transplantations)

Tissue/transplant	Reference
Nerve	Mackinnon and Hudson 1992, Mackinnon et al. 2001
Tendon	Guimberteau et al. 1992
Skin	Wendt et al. 1994
Bone and joint	Hofmann et al. 1995, 1998
Vessel	Carpenter and Tomaszewski 1997
Muscle	Jones et al. 1998
Larynx	Strome et al. 2001
Abdominal wall	Levi et al. 2003
Tongue	BBC News 2003, Birchall 2004

Figure 1. Doctors from Christine M. Kleinert Institute in Louisville, Kentucky, performing the first US hand transplantation in January 1999. The teams of surgeons were led by Dr. Warren C. Breidenbach III (second from the right).

Figure 2. Functional results of the first US hand transplant recipient at the 5-year follow-up: a) extension, b) flexion, c) supination, and d) pronation.

Figure 3. (a) Clinical signs of acute rejection of the skin in the second US hand transplant recipient. Note the maculopapular rash and edema in the donor allograft, in the proximal triangular area.

Figure 3. (b) Histological confirmation of moderate acute cellular rejection. Skin biopsy revealing perivascular and dermal lymphocyte infiltration, and mild degeneration of epidermis (hematoxylin and eosin, × 40).

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