Human papillomavirus and infiltration of CD8- and Foxp3-positive immune cells in sinonasal inverted papillomas

Figures & data

Table 1. Descriptive data on patients diagnosed with inverted papilloma in Stockholm between 2001 and 2010 per HPV status.

	Study population, N = 98	HPV+ n = 12	HPV− n = 86	p
Sex, n (%)
Males	68 (69.4)	9 (13,2)	59 (86.8)
Females	30 (30.6)	3 (10.0)	27 (90.0)	.68
Age at diagnosis
Median	59.5	42.5	60
Mean	58.0	45.6	59.6
Range	18–89	24–82	18–89	.03
Radicality
Yes	46 (46.9)	7 (58.3)	39 (45.3)
No	52 (53.1)	5 (41.7)	47 (54.7)	.40
Recurrence
Yes	40 (40.8)	4 (33.3)	36 (41.9)
No	58 (59.2)	8 (66.7)	50 (58.1)	.62
Dysplasia
Yes	10 (10.2)	3 (25.0)	7 (8.1)
No	88 (89.8)	9 (75.0)	79 (91.9)	.10

Figure 1. Boxplot with number of FoxP3-positive cells per high-power field in HPV-positive and negative samples.

Figure 2. Kaplan-Meier curves with time to recurrence in patients treated with radical surgery and patients treated with non-radical surgery.

Table 2. Hazard ratios for recurrence in HPV-positive and negative patients.

Prognostic factor	HR	Confidence interval	p
HPV	0.49	0.17–1.38	.18
Radicality	0.36	0.18–0.71	.03
Male, gender	1.15	0.59–2.24	.68
Age > 50	0.75	0.40–1.42	.38
CD8+	0.81	0.43–1.51	.51
FoxP3+	0.94	0.50–1.77	.86