Abstract
Background: Squamous cell carcinoma (SCC) is the most common type of head and neck cancer, and head and neck squamous cell carcinoma (HNSCC) was proved to having a high prevalence of perineural invasion (PNI). Although some reports have revealed a relationship between PNI and the prognosis in HNSCC patients, the contribution of PNI to the prognosis remains unclear.
Objectives: This study was aimed to comprehensively and quantitatively summarize the prognostic value of PNI for the survival of patients with HNSCC.
Material and methods: We conducted PubMed and EMBASE to identify all relevant studies. A meta-analysis and subgroup analysis were performed to clarify the prognostic role of PNI.
Results: A total of 18 studies (n = 3894) were included. 989 (25.4%) of the 3894 patients exhibited positive PNI, PNI was shown to be significantly associated with overall survival (OS) [hazard ratio (HR): 2.8, 95% confidence interval (CI): 1.88–4.16], disease-free survival (DFS) (HR = 2.42, 95% CI: 1.92–3.05) and disease-specific survival (DSS) (HR = 2.60, 95% CI: 1.86–3.63).
Conclusions: The presence of PNI significantly affected OS, DFS and DSS in patients with HNSCC.
背景:鳞状细胞癌(SCC)是最常见的头颈癌类型;头颈部鳞状细胞癌(HNSCC)被证明具有高度的神经周浸润(PNI)。尽管一些报道揭示了PNI与HNSCC患者预后之间的关系, 但PNI对预后的作用仍不清楚。
目的:本研究旨在全面地、定量地总结PNI对HNSCC患者生存的预后价值。
材料和方法:我们进行了PubMed和EMBASE, 以识别所有相关研究。进行了荟萃分析和亚组分析, 以阐明PNI的预后作用。
结果:共纳入18项研究(n = 3894)。 3894名患者中有989名(25.4%)表现出阳性PNI, PNI显示与总生存率(OS)显著相关【风险比(HR):2.8, 95%置信区间(CI):1.88-4.16】, 疾病 - 自由存活(DFS)(HR = 2.42, 95%CI:1.92-3.05)和疾病特异性存活(DSS)(HR = 2.60, 95%CI:1.86-3.63)。
结论:PNI的存在显著影响着HNSCC患者的OS, DFS和DSS。
Disclosure statement
The authors report no conflict of interest in this study.