Abstract
Background: Sinonasal squamous cell carcinoma (SCC) is a rare tumor arising either de novo or in association with inverted papillomas (IPs).
Objectives: The aim of this study was to investigate and compare the oncological features and prognosis of patients with sinonasal SCCs based on their etiology.
Material and methods: The medical records of 117 patients who had been diagnosed with de novo SCC or those arising from IP (IP-SCC) were retrospectively reviewed. In situ hybridization analyses to detect HPV 16/18DNA and p16 immunohistochemistry were also performed in 10 cases with IP-SCC.
Results: The three-year disease-specific survival (DSS) rate was higher in cases with T1, 2 and 3 than in cases with T4 in both tumor groups. T4 cases with de novo SCC had a better DSS than those with IP-SCCs. HPV16/18 was not detected in any of the 10 IP-SCCs.
Conclusions and significance: T4 cases with de novo SCC tended to have a better DSS than those with IP-SCC. Since some T4 patients with IP-SCC were found to have a highly aggressive disease, careful treatment planning should be performed. High-risk HPV may not play a vital role in the carcinomatous transformation of most IP-SCC cases.
Chinese abstract
背景:鼻窦鳞状细胞癌(SCC)是一种从头发生的或者是与倒置性乳头状瘤(IPs)相关的罕见肿瘤。
目的:本研究的目的是根据病因对鼻窦鳞状细胞癌的肿瘤学特征和预后进行研究并比较。
材料和方法:117例被诊断从头生长的SCC或由IP产生的SCC(IP-SCC)的患者的病历进行了回顾性审查。用于检测HPV 16 / 18DNA和p16免疫组化的原位杂交分析还用来检测10例IP-SCC患者 。
结果:T1、2和3的三年特定疾病存活率(DSS)高于在两个肿瘤组的T4的存活率。从头生长的SCC T4病例的DSS优于那些IP-SCC病例。在10个IP-SCC中均未检测到HPV16 / 18。
结论和意义:从头生长SCC的T4病例的DSS往往比IP-SCC更好。由于发现一些T4 IP-SCC患者患有高度侵袭性疾病, 因此应制定细致的治疗计划。在大多数IP-SCC病例的癌变过程中, 高风险HPV可能没有很大的影响。
Disclosure statement
No potential conflict of interest was reported by the author(s).