OnabotulinumtoxinA injection towards the SPG for treating symptoms of refractory chronic rhinosinusitis with nasal polyposis: a pilot study

Kent Are Jamtøya Department of Maxillofacial Surgery, St. Olavs University Hospital, Trondheim, Norway;b Department of Neuromedicine and Movement Science, NTNU, Norwegian University of Science and Technology, Trondheim, Norway;c Department of Neurology and Clinical Neurophysiology, St. Olavs University Hospital, Trondheim, NorwayCorrespondence[email protected]

https://orcid.org/0000-0002-4262-0908 View further author information

Erling Tronvikb Department of Neuromedicine and Movement Science, NTNU, Norwegian University of Science and Technology, Trondheim, Norway;d Department of Neurosurgery, St. Olavs University Hospital, Trondheim, NorwayView further author information

Daniel Fossum Bratbakb Department of Neuromedicine and Movement Science, NTNU, Norwegian University of Science and Technology, Trondheim, Norway;e Department of Otolaryngology, Head and Neck Surgery, St. Olavs University Hospital, Trondheim, NorwayView further author information

Joan Crespib Department of Neuromedicine and Movement Science, NTNU, Norwegian University of Science and Technology, Trondheim, Norway;d Department of Neurosurgery, St. Olavs University Hospital, Trondheim, NorwayView further author information

Lars Jacob Stovnerb Department of Neuromedicine and Movement Science, NTNU, Norwegian University of Science and Technology, Trondheim, Norway;d Department of Neurosurgery, St. Olavs University Hospital, Trondheim, NorwayView further author information

Irina Aschehougb Department of Neuromedicine and Movement Science, NTNU, Norwegian University of Science and Technology, Trondheim, NorwayView further author information

Wenche Moe Thorstensenb Department of Neuromedicine and Movement Science, NTNU, Norwegian University of Science and Technology, Trondheim, Norway;c Department of Neurology and Clinical Neurophysiology, St. Olavs University Hospital, Trondheim, Norway

https://orcid.org/0000-0002-4898-6169 View further author information

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Figures & data

Figure 1. MultiGuide, a novel injection device to perform navigation-assisted administration of botulinum toxin toward the sphenopalatine ganglion.

Table 1. Demographics of the sample.

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Figure 2. Adverse events, demonstrating the number of patients with adverse events resolved 12 weeks after injection.

Figure 3. Graphical representation of main efficacy outcome (a) nasal obstruction and (b) rhinorrhea measured on a 100 mm visual analogue scale (VAS) (y-axis), with 0 representing ‘not troublesome’ and 100 ‘worst thinkable troublesome’, from 4-weeks preoperatively to weeks 1–12 after injection. This figure demonstrates the decreased level of nasal obstruction from baseline to after injection. (a) Nasal obstruction (b) rhinorrhea x-axis: Weeks before and after injection y-axis: VAS: Visual analogue scale.

Table 2. Main efficacy outcome (10 patients).

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Table 3. Secondary efficacy outcome.

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OnabotulinumtoxinA injection towards the SPG for treating symptoms of refractory chronic rhinosinusitis with nasal polyposis: a pilot study

Table 1. Demographics of the sample.

Table 2. Main efficacy outcome (10 patients).

Table 3. Secondary efficacy outcome.

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OnabotulinumtoxinA injection towards the SPG for treating symptoms of refractory chronic rhinosinusitis with nasal polyposis: a pilot study

Figures & data

Table 1. Demographics of the sample.

Table 2. Main efficacy outcome (10 patients).

Table 3. Secondary efficacy outcome.

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