Effect of combining batroxobin with acupuncture treatment on hearing recovery in patients with sudden sensorineural hearing loss

Abstract

Background

The effect of batroxobin on hearing recovery in patients with Sudden Sensorineural Hearing Loss (SSNHL) is still controversial, and acupuncture shows auxiliary benefits for SSNHL

Objectives

To investigate the effectiveness of combining acupuncture with batroxobin therapy for patients with SSNHL.

Material and Methods

One hundred and fifty-six patients with SSNHL were retrospectively enrolled in this study, and categorized into the control group (only batroxobin treatment) and observation group (batroxobin and acupuncture treatment). Pure Tone Audiograms (PTA) threshold and clinical outcomes of hearing recovery were compared. Logistic regression analysis was used to evaluate the association between hearing recovery and potential risk factors.

Results

Compared to the control group, the observation group had a higher overall effective rate (p = 0.006) and improvement in PTA threshold (p = 0.007). Among SSNHL patients with high-frequency and flat-type hearing loss, observation group demonstrated superior hearing recovery post-treatment compared to the control group (p < 0.05). Additionally, hearing recovery in patient with SSNHL were associated with SSNHL types, disease duration, neutrophil count and acupuncture (p < 0.05).

Conclusions and Significance

Combining batroxobin and acupuncture treatments enhences the improvement of hearing recovery in SSNHL patients compared to only batroxobin treatments, especially high-frequency and flat-type hearing loss.

Chinese Abstract

背景

巴曲酶对突发性神经性听力损失(SSNHL)患者听力恢复的影响仍具争议性；针灸对SSNHL有辅助作用。

目的

探讨联合针灸和巴曲酶疗法对SSNHL患者的疗效。

材料与方法

回顾性纳入156例SSNHL患者, 将他们分为对照组(仅巴曲酶治疗)和观察组(巴曲酶联合针灸治疗)。比较两组的纯音听力图(PTA)阈值和听力恢复的临床结果。采用Logistic回归分析评估听力恢复与潜在危险因素之间的关联。

结果

与对照组相比, 观察组的总有效率较高(p = 0.006), 而且PTA阈值改善率也较高(p = 0.007)。在高频扁平型听力损失的SSNHL患者中, 观察组治疗后听力恢复优于对照组(p < 0.05)。此外, SSNHL患者的听力恢复与SSNHL类型、疾病持续时间、中性粒细胞计数和针灸有相关性(p < 0.05)。

结论和意义

与仅使用巴曲酶治疗相比, 巴曲酶和针灸联合治疗可增强SSNHL患者的听力恢复, 尤其是针对高频扁平型听力损失。

Keywords:

• Sudden sensorineural hearing loss
• batroxobin
• acupuncture
• pure tone audiograms
• clinical effectiveness

Disclosure statement

No potential conflict of interest was reported by the author(s).

Data availability statement

The data are available from the corresponding author on reasonable request.

Additional information

Funding

The author received no financial support for the research, authorship, and/or publication of this article.