Electrochemical Behavior and Application of Pirarubicin at Gold Nanoparticles–Modified Indium Tin Oxide Electrode

Abstract

A new type of gold nanoparticles–attached indium tin oxide electrode was made. By SEM and EDS, the as‐prepared gold nanoparticles–modified ITO electrode was characterized. This modified electrode has been used for the determination of pirarubicin (THP) in urine by cyclic voltammetry. Compared to a bare ITO electrode, the modified electrode exhibited a marked enhancement in the current response. Liner calibration curves are obtained in the range 5×10⁻⁹mol/L∼1.5×10⁻⁶ mol/L with a detection limit of 1×10⁻⁹ mol/L. The percentage of the recoveries ranged from 99.3% to 106.3%. The practical analytic utility of the method is illustrated by quantitative determination of THP in urine.

Keywords:

• Pirarubicin
• gold nanoparticles–modified ITO electrode
• cyclic voltammetry
• electrochemical behavior

One of the authors (S.L.) would like to thank Haixia Bao for her contributions to the translation of the paper.