Voltammetric Behavior and Determination of Cinnarizine in Pharmaceutical Formulations and Serum

Abstract

The electrochemical reduction of cinnarizine was investigated by cyclic and linear sweep adsorptive voltammetry at glassy carbon electrode in Britton-Robinson buffers over the pH range 2.5–11.5. For analytical purposes, a well-defined adsorption-controlled cathodic peak was obtained at pH 2.5. By cathodic adsorptive linear sweep voltammetry, a linear calibration plot was obtained in the range of 2.0 × 10⁻⁷ to 5.0 × 10⁻⁶ mol L⁻¹ with detection limit of 9.0 × 10⁻⁹ mol L⁻¹. The method was successfully applied to the determination of cinnarizine in commercial formulations with mean recovery and relative standard deviation of 100.24% and 1.46, respectively. The proposed method was also applied for drug determination in spiked serum samples by applying the standard addition method with a mean recovery of 97.80% and standard deviation of 3.06.

Keywords:

• Adsorptive voltammetry
• cinnarizine
• pharmaceuticals
• serum

Notes

^a Average of four determinations.

^a Average of five determinations.

^b ADCO Co.

^c Minapharm-Janssn Co.

^a Average of five determinations.