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Analytical Letters Volume 41, 2008 - Issue 18
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PHARMACEUTICAL ANALYSIS

Validation of a Quantitative Method Determination of Estradiol in Pharmaceutical Products using UV-Vis Molecular Absorption Spectrometry

Ileana Liliana Popescu University of Bucharest, Faculty of Chemistry, Department of Analytical Chemistry, Bucharest, Romania
,
Hassan Y. Aboul-Enein Pharmaceutical and Medicinal Chemistry Department, National Research Centre, Dokki, Cairo, EgyptCorrespondence[email protected]
,
Ion G. Tănase University of Bucharest, Faculty of Chemistry, Department of Analytical Chemistry, Bucharest, Romania
,
Ioana Ghica University of Bucharest, Faculty of Chemistry, Department of Analytical Chemistry, Bucharest, Romania
&
Camelia Bala University of Bucharest, Faculty of Chemistry, Department of Analytical Chemistry, Bucharest, Romania
Pages 3272-3296 | Received 27 Aug 2008, Accepted 10 Sep 2008, Published online: 04 Dec 2008
 
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Abstract

This article describes the development and validation of a quantitative analytical method for determination of estradiol in several pharmaceutical products (powder, tablets, cream, solutions for injection) using UV-vis molecular absorption spectrometry. The proposed method is accurate, precise, sensitive, and selective and can be used in quality control laboratories.

Notes

Notes. Sample 1: 0.5 mL estradiol stock solution + 5 ml EtOH + NaOH 0.1 N to 50 mL volumetric flask. Sample 2: 3.0 mL estradiol stock solution + 5 ml EtOH + NaOH 0.1 N to 50 mL volumetric flask. Sample 3: 7.0 mL estradiol stock solution + 5 ml EtOH + NaOH 0.1 N to 50 mL volumetric flask.

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