Room-Temperature Ionic Liquid and Multi-Walled Carbon Nanotube Composite Modified Carbon-Ceramic Electrode as a Sensitive Voltammetric Sensor for Indomethacin

Abstract

The electrochemical behavior of indomethacin on the surface of a carbon-ceramic electrode modified with multi-walled carbon nanotubes and an ionic liquid composite film is reported. The results show that the nano-structured film exhibited excellent enhancement effects on the electrochemical oxidation of indomethacin. The developed sensor presented a linear response to indomethacin over the concentration range from 1 to 50 µM with a detection limit of 0.26 µM. The proposed modified electrode was employed for the determination of indomethacin in biological and pharmaceutical samples using differential pulse voltammetry.

Keywords:

• Carbon nanotube
• Indomethacin
• Ionic liquid
• Modified electrode

Acknowledgments

The authors gratefully acknowledge the Research Council of Islamic Azad University Ahar Branch for financial support to carry out this research work.