Electrochemical Determination of Dopamine Using a Novel Perylenediimide-Derivative Modified Carbon Paste Electrode

ABSTRACT

A novel perylenediimide derivative, N,N′-bis(4-{2-[2-(2-methoxyethoxy ethoxy]ethoxy}phenyl)-3,4:9,10-perylene tetracarboxydiimide, was utilized for the modification of a carbon paste electrode to develop a practical and sensitive electrochemical sensor for dopamine detection. The effects of experimental parameters (modifier amount, pH, and scan rate) on the dopamine peak current were examined. The performance of the modified carbon paste electrode was evaluated under optimum conditions and 4.6-fold increase in the peak current was obtained compared to an unmodified carbon paste electrode. The linear range was between 1 and 100 µM dopamine and the limits of detection and quantification were 0.011 and 0.036 µM, respectively. The developed sensor was also applied for the quantitative determination of dopamine in injections and promising results were obtained.

KEYWORDS:

• Carbon paste electrode
• dopamine
• dopamine hydrochloride injection
• perylenediimide
• pharmaceutical