Electrochemical Determination of Dexrazoxane by Differential Pulse Voltammetry (DPV) Using a Graphene Oxide Nanosheet Modified Pencil Graphite Electrode (PGE)

Abstract

Dexrazoxane is a drug that protects cancer patients undergoing chemotherapy against heart attacks that may be caused by anthracyclines. However, there is insufficient information about whether taking dexrazoxane increases the risk of developing a new type of cancer. In this study, electrochemical determination of dexrazoxane (Dex) was performed by a graphene oxide (GRPox) based disposable sensor. GRPox was synthesized and characterized by X-ray diffraction (XRD), energy dispersive X-Ray spectroscopy (EDX), and transmission electron microscopy (TEM). The GRPox-modified electrodes provide 25% signal enhancement for dexrazoxane. In this study, a detection limit of 1.24 µg/mL was obtained for dexrazoxane with advantages of disposability, low cost, and easy production.

Keywords:

• Dexrazoxane
• differential pulse voltammetry
• electrochemistry
• graphene oxide nanosheets
• pencil graphite electrode

Acknowledgments

F. A would like to thank the Ph.D. scholarship awarded by TÜBİTAK 2211 C and Higher Education Council of Turkey (YOK)100/2000 Ph.D. program.

This research did not receive any specific grant from funding agencies in the public, commercial, or not-for-profit sectors.

Author contributions statement

Fatma Akpınar: methodology, software, investigation, formal analysis. Kübra Gençdağ Şensoy: investigation, formal analysis, writing – review and editing. Mihrican Muti: conceptualization, methodology, formal analysis, visualization, writing – original draft, writing - review and editing.

Additional information

Funding

This study was funded by T?rkiye Bilimsel ve Teknolojik Arastirma Kurumu;Yükseköğretim Kurulu.