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International Journal of Neuroscience Volume 116, 2006 - Issue 3
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FLUOXETINE ALTERS MU OPIOID RECEPTOR EXPRESSION IN OBESE ZUCKER RAT EXTRAHYPOTHALAMIC REGIONS

ITZIAR CHURRUCA Department of Nutrition and Food Science, Faculty of Pharmacy University of the Basque Country, Vitoria, Spain
,
MARÍA P. PORTILLO Department of Nutrition and Food Science, Faculty of Pharmacy University of the Basque Country, Vitoria, Spain
,
JOSÉ MARÍA ZUMALABE Department of Personality, Evaluation and Psychological Treatments Faculty of Pharmacy University of the Basque Country, Vitoria, Spain
,
MARÍA T. MACARULLA Department of Nutrition and Food Science, Faculty of Pharmacy University of the Basque Country, Vitoria, Spain
,
LAURA SÁENZ DEL BURGO Department of Physiology, Faculty of Pharmacy, University of the Basque Country, Vitoria, Spain
,
JON ZARATE Department of Physiology, Faculty of Pharmacy, University of the Basque Country, Vitoria, Spain
&
ENRIQUE ECHEVARRÍA Department of Physiology, Faculty of Pharmacy, University of the Basque Country, Vitoria, Spain
 show all
Pages 289-298 | Received 10 Feb 2005, Published online: 07 Jul 2009
 
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Abstract

The aim of this article was to describe the effects of chronic fluoxetine on mu opioid receptor expression in obese Zucker rat extrahypothalamic regions. Male obese Zucker (fa/fa) rats were administered with fluoxetine (10 mg/kg; i.p.) daily for two weeks. Brain regional immunostaining for mu opioid receptor was carried out. An increase in the numbers of neural cells immunostained for mu opioid receptor in caudatus-putamen, dentate gyrus, lateral septum, amygdala, and frontal, parietal, and piriform cortices was observed. Increased mu opioid receptor expression in the central amygdaloid nuclei suggests a decreased opioidergic tone at this level that could be involved in fluoxetine anorectic action.

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