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International Journal of Neuroscience Volume 116, 2006 - Issue 8
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MEMORY IMPROVEMENT WITH TREATMENT OF HYPOTHYROIDISM

KAREN J. MILLER Department of Psychiatry and Biobehavioral Sciences, UCLA NPI-H, Los Angeles, California, USA
,
THOMAS D. PARSONS Department of Psychiatry and Biobehavioral Sciences, UCLA NPI-H, Los Angeles, California, USA; Department of Neurology School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA
,
PETER C. WHYBROW Department of Psychiatry and Biobehavioral Sciences, UCLA NPI-H, Los Angeles, California, USA
,
KATJA VAN HERLE Department of Medicine, UCLA Division of Endocrinology, Los Angeles, California, USA; Department of Psychiatry and Behavioral Sciences, Stanford School of Medicine, Palo Alto, California, USA
,
NATALIE RASGON Department of Medicine, UCLA Division of Endocrinology, Los Angeles, California, USA; Department of Psychiatry and Behavioral Sciences, Stanford School of Medicine, Palo Alto, California, USA
,
ANDRE VAN HERLE Department of Medicine, UCLA Division of Endocrinology, Los Angeles, California, USA
,
DOROTHY MARTINEZ Department of Medicine, UCLA Division of Endocrinology, Los Angeles, California, USA
,
DAN H. SILVERMAN Department of Molecular and Medical Pharmacology, Los Angeles, California, USA
&
MICHAEL BAUER Department of Psychiatry and Biobehavioral Sciences, UCLA NPI-H, Los Angeles, California, USA; David Geffen School of Medicine, UCLA, Los Angeles, California, USA; Department of Psychiatry and Psychotherapy, Charité—University Medicine Berlin Campus Charité Mitte, Berlin, Germany
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Pages 895-906 | Received 29 Mar 2005, Published online: 07 Jul 2009
 
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Abstract

The consequences of inadequate thyroid hormone availability to the brain and treatment effects of levothyroxine on cognitive function are still poorly understood. This study prospectively assessed the effects of thyroid replacement therapy on cognitive function in patients suffering from biochemical evidenced, untreated hypothyroidism. Significant effects between the untreated hypothyroid group and control group were limited to verbal memory retrieval. When assessing the effects of 3-month treatment, results revealed that the treated hypothyroid group had significant increased verbal memory retrieval. Results suggest that specific memory retrieval deficits associated with hypothyroidism can resolve after replacement therapy with levothyroxine.

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