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Journal of Macromolecular Science, Part B
Physics
Volume 53, 2014 - Issue 6
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Original Articles

Influence of Nano-Bioactive Glass (NBG) Content on Properties of Gelatin-Hyaluronic Acid/NBG Composite Scaffolds

Zhihua ZhouKey Laboratory of Theoretical Chemistry and Molecular Simulation of Ministry of Education, Hunan University of Science and Technology, Xiangtan, P. R. China;Hunan Province College Key Laboratory of QSAR/QSPR, Hunan University of Science and Technology, Xiangtan, P. R. China;School of Chemistry and Chemical Engineering, Hunan University of Science and Technology, Xiangtan, P. R. ChinaCorrespondence[email protected]
,
Siliang HeSchool of Chemistry and Chemical Engineering, Hunan University of Science and Technology, Xiangtan, P. R. China
,
Baoli OuSchool of Chemistry and Chemical Engineering, Hunan University of Science and Technology, Xiangtan, P. R. China
,
Tianlong HuangDepartment of Orthopedics, the Second Xiangya Hospital, Central South University, Changsha, P. R. China
,
Wennan ZengSchool of Chemistry and Chemical Engineering, Hunan University of Science and Technology, Xiangtan, P. R. China
,
Lihua LiuSchool of Chemistry and Chemical Engineering, Hunan University of Science and Technology, Xiangtan, P. R. China
,
Qingquan LiuSchool of Chemistry and Chemical Engineering, Hunan University of Science and Technology, Xiangtan, P. R. China
,
Jian ChenSchool of Chemistry and Chemical Engineering, Hunan University of Science and Technology, Xiangtan, P. R. China
,
Yanmin ZhaoSchool of Chemistry and Chemical Engineering, Hunan University of Science and Technology, Xiangtan, P. R. China
,
Zhongmin YangSchool of Chemistry and Chemical Engineering, Hunan University of Science and Technology, Xiangtan, P. R. China
&
Dafu CaoSchool of Chemistry and Chemical Engineering, Hunan University of Science and Technology, Xiangtan, P. R. China
 show all
Pages 1145-1155 | Received 17 Mar 2013, Accepted 24 Jan 2014, Published online: 11 Jun 2014
 
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Abstract

The development of three-dimensional (3-D) scaffolds with highly open porous structure is one of the most important issues in tissue engineering. A novel nanocomposite scaffold of gelatin (Gel), hyaluronic acid (HA), and nano-bioactive glass (NBG) was prepared by blending NBG with a Gel and HA solution followed by lyophilization. The effects of NBG content on the properties of the Gel-HA/NBG composite scaffolds, including the morphologies, porosity, compressive strength, swelling behavior, cell viability and alkaline phosphatase (ALP) activity, were investigated. Porous composite scaffolds with interconnected pores were obtained and the pores became cylindrical with increasing NBG content. The porosity percent and swelling ability decreased with increasing NBG content; however, the compressive strength, cell viability and ALP activity were enhanced. All the results showed the addition of NBG particles can improve the physicochemical and biological properties and the Gel-HA/NBG composite scaffolds exhibited good potential for tissue engineering applications.

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