Figures & data
Figure 1. Spinal nociceptive network and mechanisms of SCS. Electrical stimulation of the dorsal column activates Aβ-fibers. Antidromic activation of Aβ-fibers results in the activation of GABAergic interneurons in the dorsal horn, causing inhibition of pain transmission via nociceptive-specific projection neurons and wide dynamic range neurons (gate control theory). Orthodromic activation of Aβ-fibers initiates the supraspinal feedback loop that modulates pain transmission in the dorsal horn through descending serotonergic and noradrenergic projections. (adapted from Smits et al. [Citation16])
![Figure 1. Spinal nociceptive network and mechanisms of SCS. Electrical stimulation of the dorsal column activates Aβ-fibers. Antidromic activation of Aβ-fibers results in the activation of GABAergic interneurons in the dorsal horn, causing inhibition of pain transmission via nociceptive-specific projection neurons and wide dynamic range neurons (gate control theory). Orthodromic activation of Aβ-fibers initiates the supraspinal feedback loop that modulates pain transmission in the dorsal horn through descending serotonergic and noradrenergic projections. (adapted from Smits et al. [Citation16])](/cms/asset/a363ccf2-e2a4-4c9a-a104-d41766f7d2dc/ipgm_a_1769393_f0001_c.jpg)