Reference interval transference of common clinical biomarkers

Figures & data

Table 1. Biomarkers that can be transferred between measurement systems using Abbot Architect as comparative system.

	Biomarkers	Roche Cobas 6000 [8]	Roche Modular-P [8]	Ortho VITROS 5600 [10]	Beckman Coulter [11]	Beckman Coulter DxC [12]	Beckman Coulter AU [13]	Siemens Vista [11]
Chemistry	Bilirubin, direct		Y	Y	Y		Y	Y
	Bilirubin, total	Y	Y		Y	Y	Y	Y
	Calcium		N	N	Y	N	N	Y
	CO2			N	N	N	N	N
	Creatinine (enzymatic)	Y	Y	Y		Y	Y	Y
	Creatinine (Jaffe)				Y
	Magnesium	N	N	Y	N	Y	Y	N
	Iron		Y	Y		Y	Y	Y
	Phosphate		Y	Y	N	Y	Y	Y
	Phosphorus					N
	Bicabonate (HCO3^–)	N	N
	Urea		Y	Y		Y	Y
	Uric acid		Y	Y	Y	Y		Y
Enzymes	Alkaline phosphatase (ALP)		Y	Y	Y	Y	Y	Y
	ALT (with pyridoxal phosphate)		Y	Y	Y	Y	Y	Y
	ALT (without pyridoxal phosphate)		Y
	Amylase（AMY）	Y	Y	Y	Y	Y	Y	Y
	AST AY (with pyridoxal phosphate)		Y	Y	Y	Y	Y	Y
	AST (without pyridoxal phosphate)		Y
	Gamma-glutamyltransferase (GGT)	Y	Y	Y	N	Y	Y	N
	Lactate dehydrogenase (LDH)		Y	Y	Y	Y	Y	Y
	Lipase			Y				Y
	Cholinesterase			Y
Lipids/lipoproteins	Apolipoprotein B (Apo B)	Y	Y	Y		Y	Y	Y
	Apolipoprotein A1 (Apo A1)			Y
	Cholesterol (CHO)		Y	Y		Y	Y	Y
	HDL-cholesterol (HDL-C)	Y	Y	Y	Y	Y	Y
	Triglycerides (TG)	Y	Y	Y	Y	Y	Y	Y
Proteins	Albumin G		Y	Y
	Albumin P	Y	Y	Y	Y	Y	Y	Y
	ComplemeN C3 (C3)	Y	Y	Y		Y	Y	Y
	ComplemeN C4 (C4)	Y	Y			Y	Y	Y
	C-Reactive protein (CRP)				Y	N		Y
	High–Sensitivity C–Reactive Protein (hsCRP)	Y	Y	Y			Y
	Haptoglobin		Y			N	Y	Y
	Immunoglobulin A (IgA)		Y	Y	Y	Y	Y	Y
	Immunoglobulin G (IgG)		Y	Y	Y	Y	Y	Y
	Immunoglobulin M (IgM)		Y	Y	Y	Y	Y	Y
	Prealbumin		N	Y	Y	Y	Y
	Transferrin	Y	Y	Y		Y	Y	Y
	ANistreptolysin-O (ASO)	Y	Y	Y		Y	Y
	Total protein (TP)		Y	Y	Y	Y	Y	Y
	Alpha-1 ANitrypsin (A1AT)			Y
	Rheumatoid FaYor (RF)	N	N

Y: Can be transferred based on statistical criteria; N: Not transferable based on statistical criteria.

Table 2. Transference of biomarkers between measurement systems.

Comparative system	Roche Modular P-800				Roche Cobas-8000		Vitros-750	Vitros-250	Beckman DXC-800	Hitachi-7600-020
Test system	Olympus-AU5400 [17]	Vitros-950 [17]	Beckman DXC-800 [18]	Vista Dimension [19]	Vitros-5600 [14][7]	Hitachi-7170 [7]	Hitachi-7600 [20]	Hitachi-7080 [7]	Hitachi-7600-020 [21]	Vitros-350 [15]	Vitros-5600 [16]
Chemistry
Bilirubin, total						Y	N		Y	Y	Y
Bilirubin, direct						Y	N		Y
Urea	Y	Y			Y	Y
Uric acid	Y	Y			Y	Y	Y		Y	Y
Calcium	Y	Y			Y	N
CO2					N	N
Glu	Y	Y			Y	Y	Y		Y	Y
Creatinine	N	Y			Y	Y	Y		Y	Y	Y
Mg					N	N
Cl					N	N
Na^+					N	Y
BUN							Y		N	Y
Enzyme
ALT			Y		Y	Y	Y	Y	Y	Y
AST					Y	Y	Y	Y	Y	Y
ALP					Y	Y	Y
GGT					Y	Y	Y	Y		Y
CK			Y		Y	Y
LDH				Y	Y	Y
Proteins
TP	Y	Y	Y		Y	Y	Y		Y	Y
ALB	N	N			N	Y	Y		Y	Y
Lipids/lipoproteins
TC	Y	Y	Y							Y	Y
TG	Y	Y				Y	Y		Y	Y	Y
CHO						Y	Y		Y
HDL-C									Y	Y	Y
LDL-C									Y	Y	Y

Y: Can be transferred based on statistical criteria; N: Not transferable based on statistical criteria; ALT: alanine transaminase; BUN: blood urea nitrogen; AST: aspartate transaminase; ALP: alkaline phosphatase; GGT: gamma-glutamyl transpeptadase; CK: creatine kinase; LDH; Lactic dehydrogenase; TP: total protein; ALB: albumin; TC: total cholesterol; TG: triglyceride; CHO: cholesterol; HDL-C: high-density lipoprotein cholesterol; LDL-C: low-density lipoprotein cholesterol; Mg: magnesium; Glu: glucose.

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