Cystatin C-based equations for estimating glomerular filtration rate do not require race or sex coefficients

Figures & data

Table 1. Race coefficients used in creatinine-based GFR-estimating equations.

Population	Race coefficient or adjusted equation	Reference number
Black American	1.180	[22]
Black American	1.212	[23]
Black American	1.159	[24]
Chinese	1.233 or 1.211	[29]
Arab	1.0446	[30]
Japanese	0.808	[31]
Korean	0.73989, 0.99096, 0.9554, 1.09825, 1.04334	[32]
Thai	1.129	[33]
Turkish	0.804	[34]
Pakistani	$0.686\mathrm{\times }{\text{eGFR}}_{{\text{CKD}-\text{EPI}}^{1.059}}$	[35]
Chinese	$\text{eGFR}=627.2781\mathrm{\times }{\text{SCr}}^{-0.38089}\mathrm{\times }{\mathrm{Age}}^{-\mathrm{0.18724}}\mathrm{\times }{\mathrm{0.9286438}}^{\mathrm{if female}}$	[36]

Table 2. Cystatin C-based GFR-estimating equations without race or sex coefficients.

Equation	Population	References
$$\frac{162}{\text{cystC}}-30$$	Caucasian (Children)	[47]
$$\text{log}\hspace{0.17em}x\text{GFR}=1.962+\left[\mathrm{1.123 x}\hspace{0.17em}\text{log}\hspace{0.17em}x\frac{1}{\mathit{cystC}}\right]$$	Caucasian (Children)	[48]
$$-4.32+80.35\mathrm{\times }\frac{1}{\text{cystC}}$$	Caucasian (Adults)	[49]
$${99.43\mathrm{\times }\text{cystC}}^{-1.5837}$$	Caucasian (Children, Adults)	[50]
$$\frac{\mathrm{124}}{\mathrm{cystC}}-22.3$$	Caucasian (Adults)	[46]
$$84.69\mathrm{\times }{\mathrm{cystC}}^{-\mathrm{1.680}}\mathrm{\times }{\mathrm{1.384}}^{\mathrm{if}\mathit{\text{<14}}\mathrm{years}}$$	Caucasian (Children, Adults)	[51]
$$89.126\mathrm{\times }{\mathrm{cystC}}^{\mathrm{-1.675}}$$	Caucasian (Adults)	[52]
$$\text{Native}\mathrm{ }\text{CKD:}\mathrm{ }66.8\mathrm{\times }{\text{cystC}}^{-1.30}$$ $$\text{Transplant}\mathrm{ }\text{recipient:}\mathrm{ }76.6\mathrm{\times }{\text{cystC}}^{-1.16}$$	US adults	[53]
$$79.901\mathrm{\times }{\text{cystC}}^{-1.4389}$$	Caucasian	[54]
$$130\mathrm{\times }{\text{cystC}}^{-1.069}\mathrm{\times }{\text{age}}^{-0.117}-7$$	Caucasian, Asian, African American (Children, adults)	[41]
$$91\mathrm{\times }{\text{cystC}}^{-1.213}$$	Caucasian (Children)	[55]
$$\frac{\mathrm{107.3}}{\left(\frac{\mathit{cystC}}{\mathit{QcystC}}\right)}\mathrm{\times }{\mathrm{0.988}}^{\mathit{\text{Age-40 (if>40years)}}}$$ QcystC = 0.82 if age <70 years or QcystC = 0.95 if age >70 years	Mainly Caucasian (Children, Adults)	[58]

The equations of references [41,55,58] are based upon the international cystatin C calibrator [42].

Levey AS, Bosch JP, Lewis JB, et al. A more accurate method to estimate glomerular filtration rate from serum creatinine: a new prediction equation. Modification of diet in renal disease study group. Ann Intern Med. 1999;130(6):461–470.

 PubMed Web of Science ®Google Scholar

Levey AS, Coresh J, Greene T, et al. Using standardized serum creatinine values in the modification of diet in renal disease study equation for estimating glomerular filtration rate. Ann Intern Med. 2006;145(4):247–254.

 PubMed Web of Science ®Google Scholar

Levey AS, Stevens LA, Schmid CH, et al. A new equation to estimate glomerular filtration rate. Ann Intern Med. 2009;150(9):604–612.

 PubMed Web of Science ®Google Scholar

Ma YC, Zuo L, Chen JH, et al. Modified glomerular filtration rate estimating equation for Chinese patients with chronic kidney disease. J Am Soc Nephrol. 2006;17(10):2937–2944.

 PubMed Web of Science ®Google Scholar

Al-Khader AA, Tamim H, Sulaiman MH, et al. What is the most appropriate formula to use in estimating glomerular filtration rate in adult Arabs without kidney disease? Ren Fail. 2008;30(2):205–208.

 PubMed Web of Science ®Google Scholar

Matsuo S, Imai E, Horio M, et al. Revised equations for estimated GFR from serum creatinine in Japan. Am J Kidney Dis. 2009;53(6):982–992.

 PubMed Web of Science ®Google Scholar

Lee CS, Cha RH, Lim YH, et al. Ethnic coefficients for glomerular filtration rate estimation by the modification of diet in renal disease study equations in the Korean population. J Korean Med Sci. 2010;25(11):1616–1625.

 PubMed Web of Science ®Google Scholar

Praditpornsilpa K, Townamchai N, Chaiwatanarat T, et al. The need for robust validation for MDRD-based glomerular filtration rate estimation in various CKD populations. Nephrol Dial Transplant. 2011;26(9):2780–2785.

 PubMed Web of Science ®Google Scholar

Altiparmak MR, Seyahi N, Trabulus S, et al. Applicability of a different estimation equation of glomerular filtration rate in Turkey. Ren Fail. 2013;35(8):1116–1123.

 PubMed Web of Science ®Google Scholar

Jessani S, Levey AS, Bux R, et al. Estimation of GFR in South Asians: a study from the general population in Pakistan. Am J Kidney Dis. 2014;63(1):49–58.

 PubMed Web of Science ®Google Scholar

Zhou LY, Yin WJ, Zhao J, et al. A novel Creatinine-Based equation to estimate glomerular filtration rate in Chinese population with chronic kidney disease: Implications for DOACs dosing in atrial fibrillation patients. Front Pharmacol. 2021;12:615953.

 PubMed Web of Science ®Google Scholar

Bokenkamp A, Domanetzki M, Zinck R, et al. Cystatin C-a new marker of glomerular filtration rate in children independent of age and height. Pediatrics. 1998;101(5):875–881.

 PubMed Web of Science ®Google Scholar

Filler G, Lepage N. Should the schwartz formula for estimation of GFR be replaced by cystatin C formula? Pediatr Nephrol. 2003;18(10):981–985.

 PubMed Web of Science ®Google Scholar

Hoek FJ, Kemperman FA, Krediet RT. A comparison between cystatin C, plasma creatinine and the Cockcroft and Gault formula for the estimation of glomerular filtration rate. Nephrol Dial Transplant. 2003;18(10):2024–2031.

 PubMed Web of Science ®Google Scholar

Larsson A, Malm J, Grubb A, et al. Calculation of glomerular filtration rate expressed in mL/min from plasma cystatin C values in mg/L. Scand J Clin Lab Invest. 2004;64(1):25–30.

 PubMed Web of Science ®Google Scholar

Sjöström P, Tidman M, Jones I. Determination of the production rate and non-renal clearance of cystatin C and estimation of the glomerular filtration rate from the serum concentration of cystatin C in humans. Scand J Clin Lab Invest. 2005;65(2):111–124.

 PubMed Web of Science ®Google Scholar

Grubb A, Nyman U, BjöRk J, et al. Simple cystatin C-based prediction equations for glomerular filtration rate compared with the modification of diet in renal disease (MDRD) prediction equation for adults and the Schwartz and the Counahan-Barratt prediction equations for children. Clin Chem. 2005;51(8):1420–1431.

 PubMed Web of Science ®Google Scholar

Grubb A, Björk J, Lindström V, et al. A cystatin C-based formula without anthropometric variables estimates glomerular filtration rate better than creatinine clearance using the Cockcroft-Gault formula. Scand J Clin Lab Invest. 2005;65(2):153–162.

 PubMed Web of Science ®Google Scholar

Rule AD, Bergstralh EJ, Slezak JM, et al. Glomerular filtration rate estimated by cystatin C among different clinical presentations. Kidney Int. 2006;69(2):399–405.

 PubMed Web of Science ®Google Scholar

Flodin M, Jonsson AS, Hansson LO, et al. Evaluation of gentian cystatin C reagent on abbott Ci8200 and calculation of glomerular filtration rate expressed in mL/min/1.73 m2 from the cystatin C values in mg/L. Scand J Clin Lab Invest. 2007;67(5):560–567.

 PubMed Web of Science ®Google Scholar

Grubb A, Horio M, Hansson LO, et al. Generation of a new cystatin C-based estimating equation for glomerular filtration rate by use of 7 assays standardized to the international calibrator. Clin Chem. 2014;60(7):974–986.

 PubMed Web of Science ®Google Scholar

Berg UB, Nyman U, Bäck R, et al. New standardized cystatin C and creatinine GFR equations in children validated with inulin clearance. Pediatr Nephrol. 2015;30(8):1317–1326.

 PubMed Web of Science ®Google Scholar

Pottel H, Delanaye P, Schaeffner E, et al. Estimating glomerular filtration rate for the full age spectrum from serum creatinine and cystatin C. Nephrol Dial Transplant. 2017;32:497–507.

 PubMed Web of Science ®Google Scholar

Grubb A, Blirup-Jensen S, Lindström V, et al. on behalf of the IFCC working group on standardisation of cystatin C (WG-SCC). First certified reference material for cystatin C in human serum ERM-DA471/IFCC. Clin Chem Lab Med. 2010;48:1619–1621.

 PubMed Web of Science ®Google Scholar