Figures & data
Table I. Weight changes in rats before and after the treatments.
Figure 1. Immunostaining of the gastric corpus (A–E) and antral (F–J) mucosae with anti-mucin monoclonal antibodies. Gastric tissues were obtained from control rats (A, F), rats treated with 5-fluorouracil (5-FU) alone (B, G), rats treated with omeprazole (Ome+ 5-FU (C, H), rats treated with lansoprazole (Lan) + 5-FU (D, I), and rats treated with lafutidine (Laf) + 5-FU (E, J). Notice that surface epithelial mucus cells in the corpus show positive staining with RGM21, and those in the antrum show positive staining with RGM26. Original magnification×25.
Figure 2. Influence of acid antisecretory agents on the gastric corpus mucin accumulation in the 5-FU-induced gastric mucosal damage. Fr-1 hexose values corresponding to mucin content are expressed as micrograms of hexose per rat and represent means±SD. Abbreviations: 5-FU = 5-fluorouracil; Ome = omeprazole; Lan = lansoprazole; Laf = lafutidine. n=6–9 (each group); *p<0.05.
Figure 3. Immunostaining of the rat jejunal (A–E) and ileal (F–J) mucosae with anti-mucin monoclonal antibody PGM34. Small-bowel tissues were obtained from control rats (A, F), rats treated with 5-fluorouracil (5-FU) alone (B, G), rats treated with omeprazole (Ome) + 5-FU (C, H), rats treated with lansoprazole (Lan) + 5-FU (D, I), and rats treated with lafutidine (Laf) + 5-FU (E, J). Notice that goblet cells in the jejunum and ileum show positive staining with PGM34. Original magnification×25.
Figure 4. Influence of acid antisecretory agents on the jejunal (A) and ileal (B) mucin accumulation in the 5-FU-induced small-bowel mucosal damage. Fr-1 hexose values corresponding to mucin content are expressed as micrograms of hexose per rat and represent means±SD. Abbreviations: 5-FU = 5-fluorouracil; Ome = omeprazole; Lan = lansoprazole; Laf = lafutidine. n=6–9 (each group); *p<0.05.
