Serological biomarkers in triage of FIT-positive subjects?

Figures & data

Table 1. Present Danish criteria for histological diagnosis of the various adenoma categories.

HRA	Size ≥20 mm	Lesions ≥5	Resected by piece-meal technique
MRA	10 ≤ size <20 mm	3 ≤ lesions <5	High-grade neoplasia	Villous elements
LRA	Size <10 mm	Lesions <3	Low-grade neoplasia	Tubular lesions

LRA: low-risk adenoma.

Table 2. Shows fixed, increased FIT cut-off levels and number (%) of unnecessary colonoscopies defined by the levels among 1977 subjects with positive FIT result.

FIT cut-off level (ng/ml)	Spared co-lonoscopies, n (%)	Missed CRC, n (%)	Missed HRA, n (%)	Missed MRA, n (%)	Identified CRC, n (%)^a	Identified HRA, n (%)^a	Identified MRA, n (%)^a
200	644 (32)	11 (9)	52 (20)	90 (25)	5 (45)	15 (28)	41 (45)
250	868 (44)	27 (23)	78 (30)	122 (45)	10 (37)	21 (27)	50 (41)
300	1005 (51)	33 (28)	95 (36)	145 (41)	14 (42)	26 (27)	54 (37)
400	1193 (60)	43(36)	120 (46)	183 (52)	18 (42)	33 (27)	65 (35)
500	1311 (66)	47 (40)	142 (55)	204 (58)	19 (40)	44 (31)	70 (34)
1000	1977 (100)	118 (100)	260 (100)	350 (100)	52 (44)	92 (35)	123 (35)

Numbers (%) of neoplastic lesions missed at the various cut-off levels and numbers (%) of neoplastic lesions identified by analyses of serum nucleosomes.

^a Percentage of the number missed by increased FIT cut-off levels.