Dysplasia in the mucosal biopsy specimen is still a warning sign of cancer in ulcerative colitis

Figures & data

Table 1. Characteristics of colorectal cancer patients (n = 71).

Male gender	43 (60.6%)
Age, years (mean ± std deviation)	49.9 ± 11.3
Primary sclerosing cholangitis	13 (18.3%)
Median disease duration, years (n = 70)	19 (0–50)
Patients under routine surveillance (n = 66)	58 (81.7%)
Diagnosis of UC was made from the surgical specimen	3 (4.2%)
Indication for surgery
Cancer	47 (66.2%)
Dysplasia	22 (31.0%)
Fulminant colitis	1 (1.4%)
Pseudopolyposis	1 (1.4%)
Type of surgery
PC + IPAA	55 (77.5%)
Proctocolectomy with ileostomy	5 (7.0%)
Colectomy	10 (14.1%)
Excision of the pouch	1 (1.4%)
Pathological features
rectal cancer	20 (28.2%)
colonic cancer	51 (71.8%)
syncronous dysplasia	24 (33.8%)
syncronous colorectal cancer	10 (14.1%)
mucinous carcinoma (n = 69)	22 (31.0%)
grade 1/2/3/NA	18 (25.4%)/22 (31.0%)/14 (19.7%)/17 (23.9%)
stage I/II/III/IV	20 (28.2%)/24 (33.8%)/20 (28.2%)/7 (9.9%)
Cancer recurrence (n = 65)	17 (23.9%)
Death during follow-up	20 (28.2%)
From colorectal cancer	14 (19.7%)

PC + IPAA = proctocolectomy and ileal pouch-anal anastomosis.

NA = Not assessed.

Table 2. Characteristics of patients with dysplasia in the surgical specimen (n = 108).

Male gender	81 (75.0%)
Age, years (mean ± std deviation)	44.5 ± 14.0
Primary sclerosing cholangitis	24 (22.2%)
Median disease duration, years	11 (1–44)
Indication for surgery
Dysplasia	70 (64.8%)
Medical therapy failure	38 (35.2%)
Pathological features (n = 101)
low-grade dysplasia	65 (60.2%)
high-grade dysplasia	36 (33.3%)
Death during follow-up	6 (5.6%)

Figure 1. Incidence of dysplasia and cancer in the surgical specimen.

Figure 2. Kaplan–Meier curve for cancer-specific survival of 71 patients with ulcerative colitis-associated colorectal cancer.