Plasma suPAR may help to distinguish between chronic pancreatitis and pancreatic cancer

Figures & data

Table 1. Demographic data of patients admitted to hospital for their first alcohol-induced acute pancreatitis (AAP) (n = 83).

Characteristics
Gender (male/female)	75/8 (90%/10%)
Age on admission, years, median (range)	48 (25–71)
Recurrent pancreatitis during follow-up	32 (39%)
Chronic pancreatitis	12 (14%)
Diabetes mellitus	35 (42 %)
BMI (kg/m^−2), median on admission (range)	28 (19–38)
Smoking (cigarettes/day)	10 (0–50)
Alcohol abuse (g/2 months)^a	3048 (288–15,456)
Cardiovascular disease (HBP/CHD)	16 (19%)
Malignancy	3 (4%)

^aData missing on 1 patient.

HBP: high blood pressure; CHD: coronary heart disease.

Table 2. Characteristics of patients with chronic pancreatitis (CP, n = 10) and pancreatic cancer (PC, n = 25).

Characteristics	CP	PC	p Value
Gender (male/female)	9/1 (90%/10%)	13/12 (52%/48%)	.039
Age on admission, years, median (range)	52 (43–64)	67 (56–83)	<.0001
Diabetes mellitus	8 (80%)	12 (48%)^a	.087
BMI (kg/m^−2), median on admission (range)	26.7 (23.3–31.0)	23.3 (21.1–27.1)	.049
Smoking	8 (80%)	4 (16%)	.001
Moderate drinking^b	3 (30%)	2 (8%)	.128
Cardiovascular disease (HBP/CHD)	4 (40%)	16 (64%)	.179

^a Preoperative value.

^b ≥14 portions per week.

HBP: high blood pressure; CHD: coronary heart disease.

Figure 1. (a) P-suPAR levels of patients with first alcohol-induced acute pancreatitis (AAP) on admission and during prospective follow-up (n = 83). Group 0: no chronic pancreatitis (CP) during follow-up; group 1: CP developed during follow-up. (b) P-suPAR values of patients with chronic pancreatitis (CP, n = 10) and pancreatic adenocarcinoma (PC, n = 25).

Figure 2. Receive operating characteristics (ROC) curve of P-suPAR to differentiate between chronic pancreatitis (CP) and pancreatic carcinoma (PC) (n = 35).

Table 3. Logistic regression for risk factors for pancreatic carcinoma (PC) in study population [PC and chronic pancreatitis (CP) study groups, n = 35].

Characteristics	OR	95% CI for OR	p Value
P-suPAR	12.314	1.29–117.5	.029
smoking	0.266	0.031–2.273	.226
BMI	1.097	0.864–1.392	.447