Long-term outcome of patients with acute ulcerative colitis after first course of intravenous corticosteroids

Figures & data

Table 1. Demographic and clinical characteristics of 217 patients with ulcerative colitis treated with first course of intravenous corticosteroids.

	n /Median	%/ (range)
Male	117	54
Age at index flare (year)	31	(16–81)
Disease duration at index flare (year)	0.1	(0–36)
Montreal score
E1	15	7
E2	81	37
E3	119	55
Endoscopic severity Mayo 3	107	49
UC onset at index flare	93	43
The history of prior oral Cs	84	39
Follow-uptime (year)	7.5	(0.1–10.5)

UC: ulcerative colitis; Cs: corticosteroid. Data expressed as absolute and relative frequencies and median (interquartile range).

Figure 1. Outcome of the 217 patients with ulcerative colitis treated with their first course of intravenous corticosteroids. Data expressed as absolute frequencies.

Table 2. Clinical characteristics and outcomes of 217 patients during follow-up.

	n /Median	%/ (range)
Median age for operative treatment (year)	34	(18–81)
Median time from diagnosis to colectomy (year)	2.7	(0–35)
Emergency colectomy	5	2.3
Colectomy within 1 year after index flare	26	12
Overall colectomy rate	56	26
Colectomy:	18/98	18
UC diagnosed at index flare
UC diagnosed prior to index flare	38/119	32
After initial response to CyA therapy	10/31	32
After failed therapy with infliximab	17/36	47
Thiopurine as maintenance therapy prior to index flare	6/12	50
Thiopurine started after index flare	39/143	27

UC: ulcerative colitis; CyA: cyclosporine A. Data expressed as absolute and relative frequencies and median (interquartile range).

Table 3. Predictors of response to first course of intravenous corticosteroid in 217 patients.

	Responders		Nonresponders
	n /Median	% (range)	n /Median	% (range)	p Value
Follow-up (m)	55	(0–125)	43	(12–118)
Male	102	50	15	45	.214
Age < 40 years	128	70	21	64	.268
UC extent at index flare					.341
E1	14	8	1	3
E2	66	36	15	45
E3	102	55	17	52
Endoscopic severity Mayo 3	82	51	25	76	.017
Mayo 6–9 in clinical assessment	114	62	27	82	.022
Diagnosis at index flare	84	56	9	35	.047
Cs for previous flares	70	39	16	52	.200
Maintenance therapy with thiopurines prior to index flare	10	5	2	6	.885
Clostridium difficile infection at index flare	4	2	2	6

Cs: corticosteroid.