The yield of upper gastrointestinal endoscopy in patients below 60 years and without alarm symptoms presenting with dyspepsia

Figures & data

Figure 1. Flow chart of patient selection.

Table 1. Patient characteristics and endoscopy outcomes.

Details	N of patients = 13,978
Patient characteristics
Gender (female), n (%)	8693 (62.2)
Age in years, median [IQR]	46 [36–53]
Setting
Academic, n (%)	726 (5.2)
Non-academic, n (%)	13,252 (94.8)
Major endoscopic finding^a
Present, n (%)	513 (3.7)
Absent, n (%)	13,465 (96.3)
Severe esophagitis
Esophagitis LA Grade C, n (%)	187 (1.3)
Esophagitis LA Grade D, n (%)	48 (0.3)
Ulcer
Gastric ulcer, n (%)	91 (0.7)
Duodenal ulcer, n (%)	112 (0.8)
Both, n (%)	9 (0.06)
Stricture
Esophageal stricture, n (%)	21 (0.2)
Duodenal stricture, n (%)	6 (0.04)
Suspected cancer diagnosis
Suspicion of oesophageal cancer, n (%)	16 (0.1)
Suspicion of gastric cancer, n (%)	28 (0.2)
Suspicion of duodenal cancer, n (%)	5 (0.04)
Total neoplasia, n (%)	47 (0.3)
Minor endoscopic finding^a
Present, n (%)	2178 (15.6)
Absent, n (%)	11,800 (84.4)
Suspected metaplasia
Barrett’s esophagus, n (%)	371 (2.7)
Gastric metaplasia, n (%)	18 (0.1)
Esophagitis
LA Grade A, n (%)	1217 (8.7)
LA Grade B, n (%)	677 (4.8)
No finding, n (%)	11,353 (81.2)

^aPatients can have more than one diagnosis.

Figure 2. Prevalence of cancer per age and gender.

Figure 3. Flow chart of endoscopic findings and follow-up endoscopy.

Table 2. Endoscopic findings of the follow-up upper GI endoscopies in patients with a prior negative upper GI endoscopy.

Details	Second endoscopy > 30 days N of patients = 1015
Patient characteristics
Gender (female), n (%)	693 (68.3)
Age in years, median [IQR]	47 [37–53]
Time interval between baseline and follow-up endoscopy
Days, median [IQR]	428 [158–819]
Major finding, n (%)^a	25 (0.2)
Esophagitis LA Grade C, n (%)	8 (0.1)
Esophagitis LA Grade D, n (%)	5 (0.04)
Gastric ulcer, n (%)	7 (0.05)
Duodenal ulcer, n (%)	4 (0.03)
Oesophageal stricture, n (%)	3 (0.02)
Duodenal stricture, n (%)	1 (0.01)
Suspicion of oesophageal cancer, n (%)	–
Suspicion of gastric cancer, n (%)	–
Suspicion of duodenal cancer, n (%)	–
Minor finding, n (%)^a	67 (0.5)
Suspicion of Barrett’s oesophagus, n (%)	13 (0.1)
Suspicion of gastric metaplasia, n (%)	3 (0.02)
Esophagitis LA Grade A, n (%)	37 (0.3)
Esophagitis LA Grade B, n (%)	17 (0.1)
No finding, n (%)	924 (6.6)

^a Patients can have more than one diagnosis.